Rejection of the kidney allograft.
Summary of "Rejection of the kidney allograft."
To the Editor: We believe another entity merits mention in the review article by Nankivell and Alexander (Oct. 7 issue)(1) on rejection of kidney allografts. Fidler et al. described subclinical antibody-mediated rejection in patients who have undergone ABO-incompatible kidney transplantation.(2) This form of rejection has also been reported in patients who have undergone HLA antibody-incompatible cadaveric(3),(4) or living-donor(4) kidney transplantation. In subclinical antibody-mediated rejection, the serum creatinine level is stable, but allograft biopsy specimens show glomerulitis, peritubular capillary infiltration by leukocytes, and diffuse or focal staining of peritubular capillaries with an anti-C4d antibody. These findings are often associated with . . .
Affiliation
Journal Details
This article was published in the following journal.
Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 485-6
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21288109
- DOI: http://dx.doi.org/10.1056/NEJMc1012440#SA1
Medical and Biotech [MESH] Definitions
Neopterin
A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.
Histocompatibility Testing
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Rejection (psychology)
Non-acceptance, negative attitudes, hostility or excessive criticism of the individual which may precipitate feelings of rejection.
Kidney Papillary Necrosis
A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.
PubMed Articles
Rejection of the kidney allograft.
To the Editor: We believe another entity merits mention in the review article by Nankivell and Alexander (Oct. 7 issue)(1) on rejection of kidney allografts. Fidler et al. described subclinical antibo...
Emerging drugs for the treatment of transplant rejection.
Introduction: Kidney allograft rejection is an important cause of early and late allograft failure. The importance of antibody-mediated rejection especially in the context of late allograft failure h...
Granzyme B (GZMB) and perforin 1 gene (PRF1) are key effector molecules of cytotoxic T lymphocytes, in causing acute and chronic solid organ transplant rejection. In this study, we analyzed the impact...
BACKGROUND: Pancreas and kidney allograft function is routinely monitored with serum studies (amylase, lipase, and creatinine). Increased levels commonly prompt tissue biopsy, to diagnose cause of gra...
B lymphocytes differentially influence acute and chronic allograft rejection in mice.
The relative contributions of B lymphocytes and plasma cells during allograft rejection remain unclear. Therefore, the effects of B cell depletion on acute cardiac rejection, chronic renal rejection,...
Clinical Trials
Genomics of Chronic Renal Allograft Rejection (The GoCAR Study)
Doctors have had success preventing certain types of kidney transplant rejection by suppressing the immune system. However, an individual's genetic make-up and the strength of an immune r...
New Strategies for Non-Invasive Detection of Chronic Allograft Nephropathy
The purpose of this study is to help researchers find out more about a condition called "Chronic Allograft Nephropathy" (CAN). CAN is a complication that sometimes occurs after kidney tran...
The purpose of the study is to determine the safety and efficacy of two dosing regimens of daclizumab in simultaneous kidney/pancreas transplant recipients.
Efficacy of Rituximab in Acute Cellular Rejection in Renal Transplant Patients
Acute kidney allograft rejection is the major cause for a loss of graft function and has a negative impact on long-term graft survival. Anti-rejection therapy traditionally focuses on T ce...
Mesenchymal Stem Cell Transplantation in the Treatment of Chronic Allograft Nephropathy
Mesenchymal Stem Cell (MSC) have been shown to have immunosuppressive and repairing properties. the investigators will infuse expanded MSC into patients who develop Chronic Allograft Nephr...
