Endometriosis-associated ovarian carcinomas.

05:53 EDT 30th August 2015 | BioPortfolio

Summary of "Endometriosis-associated ovarian carcinomas."

To the Editor: Wiegand et al. (Oct. 14 issue)(1) report that ARID1A mutations were found in 46% of ovarian clear-cell carcinomas and in 30% of endometrioid carcinomas. This finding raises the idea that such tumors may be of müllerian rather than coelomic derivation. The three most common types of ovarian carcinoma - namely, serous, endometrioid, and mucinous - are histologically identical to tumors of the fallopian tube, endometrium, and endocervix, which are tumors known to arise from the embryonic müllerian duct.(2) To the Editor: Wiegand et al. have identified ARID1A mutations in endometriosis-associated ovarian carcinomas, providing a first report of . . .

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Journal Details

This article was published in the following journal.

Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 482-5

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PubMed Articles [1721 Associated PubMed Articles listed on BioPortfolio]

Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas.

We focused on the differences in molecular mechanisms in the early stages of endometriosis-associated ovarian endometrioid carcinoma (OEMCa) and ovarian clear cell carcinoma (OCCCa).

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Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.

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Medical and Biotech [MESH] Definitions

A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)

Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.

Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.

A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.

Methods used for assessment of ovarian function.


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