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Sarcoidosis and Small-fiber Neuropathy.

06:00 EST 8th February 2011 | BioPortfolio

Summary of "Sarcoidosis and Small-fiber Neuropathy."

Chronic pain is one of the most commonly reported symptoms among sarcoidosis patients. Not only does it significantly affect quality of life, but it also is a source of frustration for both the patient and physician because the etiology for pain often is unknown. Although patients typically complain of neuropathic-type pain, nerve conduction studies and other conventional diagnostic procedures frequently fail to reveal objective evidence of neurologic disease. However, in recent years, the growing use of specialized tests such as skin biopsy and sudomotor testing has helped to establish the diagnosis of small-fiber neuropathy as the cause of pain in these patients via objective and quantifiable means. Management of sarcoidosis small-fiber neuropathy should consist of target-directed treatment of the underlying disease and appropriate symptomatic therapy.

Affiliation

Cleveland Clinic Foundation, Neuromuscular Center, 9500 Euclid Avenue, S90, Cleveland, OH, 44195, USA, taveej2@ccf.org.

Journal Details

This article was published in the following journal.

Name: Current pain and headache reports
ISSN: 1534-3081
Pages:

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Medical and Biotech [MESH] Definitions

Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (see A FIBERS) and unmyelinated C FIBERS. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweating or facial flushing). Small fiber neuropathy can be idiopathic or associated with underlying diseases (e.g., AMYLOIDOSIS; DIABETES MELLITUS; SARCOIDOSIS; or VASCULITIS).

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