Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines.
Summary of "Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines."
Live virus vaccines provide a unique opportunity to study human CD8(+) T-cell memory in the context of a controlled, primary acute viral infection. Yellow fever virus-17D and Dryvax are two such live-virus vaccines that are highly efficacious, used worldwide and provide long-term immunity against yellow fever and smallpox respectively. In this review, we describe the properties of virus-specific memory CD8(+) T cells generated in smallpox and yellow fever vaccinees. We address fundamental questions regarding magnitude, functional quality and longevity of the CD8(+) T-cell response, which are otherwise challenging to address in humans. These findings provide insights into the attributes of the human immune system as well as provide a benchmark for the optimal quality of a CD8(+) T-cell response that can be used to evaluate novel candidate vaccines.Immunology and Cell Biology advance online publication, 8 February 2011; doi:10.1038/icb.2010.155.
Affiliation
1] Emory Vaccine Center and the Hope Clinic, Atlanta, GA, USA [2] Department of Microbiology and Immunology; Emory University School of Medicine, Atlanta, GA, USA.
Journal Details
This article was published in the following journal.
Name: Immunology and cell biology
ISSN: 1440-1711
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21301482
- DOI: http://dx.doi.org/10.1038/icb.2010.155
Medical and Biotech [MESH] Definitions
Yellow Fever Vaccine
Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.
Trench Fever
An intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by BARTONELLA QUINTANA and transmitted by the human louse.
Epidermodysplasia Verruciformis
An autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales.
Yellow Fever Virus
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
Yellow Fever
An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus.
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