Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity.
Summary of "Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity."
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. Peripheral retinal ablation with conventional (confluent) laser therapy is destructive, causes complications, and does not prevent all vision loss, especially in cases of retinopathy of prematurity affecting zone I of the eye. Case series in which patients were treated with vascular endothelial growth factor inhibitors suggest that these agents may be useful in treating retinopathy of prematurity.
Affiliation
Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston-Medical School, Houston, USA. helen.a.mintz-hittner@uth.tmc.edu
Journal Details
This article was published in the following journal.
Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 603-15
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21323540
- DOI: http://dx.doi.org/10.1056/NEJMoa1007374
Medical and Biotech [MESH] Definitions
Retinopathy Of Prematurity
A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
Pachytene Stage
The stage in the first meiotic prophase, following ZYGOTENE STAGE, when CROSSING OVER between homologous CHROMOSOMES begins.
Intravitreal Injections
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
Odontogenesis
The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).
Therapeutic Equivalency
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
PubMed Articles
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Recently, intravitreal bevacizumab (Avastin) injection has gained popularity as a potential treatment of intraocular neovascularization (CNV) associated with age related macular degenerati...
