Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review.
Summary of "Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review."
This review examines the current state of the art lab-on-a-chip and microfluidic based biosensor technologies used in the detection of cardiac biomarkers. The determination and quantification of blood based, cardiac biomarkers are crucial in the triage and management of a range of cardiac related conditions, where time delay has a major impact on short and longer-term outcomes of a patient. The design and manufacturing of biomarker detection systems are multi-disciplinary in nature and require researchers to have knowledge of both life sciences and engineering for the full potential of this field to be realised. This review will therefore provide a comprehensive overview of chip based immunosensing technology as applied to cardiac biomarker detection, while discussing the potential suitability and limitations of each configuration for incorporation within a clinical diagnostics device suitable for point-of-care applications.
Affiliation
Heriot-Watt University, MicroSystems Engineering Centre (MISEC), School of Engineering & Physical Sciences, Earl Mountbatten Building, Edinburgh, ScotlandEH14 4AS.
Journal Details
This article was published in the following journal.
Name: Lab on a chip
ISSN: 1473-0189
Pages: 569-95
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21180774
- DOI: http://dx.doi.org/10.1039/c0lc00204f
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