Ectopic ACTH-secreting neuroendocrine tumor.

00:24 EDT 30th March 2015 | BioPortfolio

Summary of "Ectopic ACTH-secreting neuroendocrine tumor."

The authors report a case of an ectopic ACTH-syndrome that resulted in severe hypercortisolism, hypokalemia, diabetes mellitus and osteoporosis. The ACTH-secreting tumor tissue was localized in the lung. The tumor was removed by segmentectomy and histological evaluation revealed an ACTH-secreting neuroendocrine tumor. After surgery, however, plasma cortisol and ACTH levels failed to decrease significantly due to subtotal tumor removal. Long-acting somatostatin analogue therapy resulted in a normalization of both plasma cortisol and ACTH levels and the clinical symptoms improved significantly. Residual tumor was removed by repeat surgery and the patient was permanently cured. Orv. Hetil., 2011, 152, 403-406.


Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház II. Belgyógyászat Miskolc.

Journal Details

This article was published in the following journal.

Name: Orvosi hetilap
ISSN: 0030-6002
Pages: 403-406


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Medical and Biotech [MESH] Definitions

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

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