Risk factors for Barrett's esophagus in Indian patients with gastro-esophageal reflux disease.

06:41 EDT 3rd August 2015 | BioPortfolio

Summary of "Risk factors for Barrett's esophagus in Indian patients with gastro-esophageal reflux disease."

Background and Aims: Barrett's esophagus (BE) is reported to be infrequent in Asians, with no data from India regarding the prevalence and risk factors for BE. We investigated the frequency and risk factors of columnar mucosa with or without specialized intestinal metaplasia (SIM) in Indian patients with gastro-esophageal reflux disease (GERD). Methods: Two hundred and seventy-eight GERD patients over two years underwent gastroscopy and a questionnaire for possible risk factors for BE. Patients with columnar mucosa on endoscopy underwent four-quadrant biopsy; BE was histologically defined as columnar mucosa with or without SIM. Patients without columnar mucosa at endoscopy were considered as controls and compared to patients with BE, and those with SIM. Results: Forty-six patients with GERD had columnar mucosa on histology (16.54%); 25 (8.99%) of these had SIM. Risk factors for BE were presence of hiatus hernia (OR 3.14 [95% CI [1.2-8.17]) and history of eructation (OR 2.28 [1.11-4.66]). Risk factors for SIM were age ≥45 years (OR 2.63 [1.03 -6.71]), hiatus hernia (OR 3.95 [1.24 - 12.56]) and history of eructation (OR 3.41 [1.19 - 9.78]). Gender, severity of symptoms, dietary factors, tobacco or alcohol use, and BMI were not associated with BE. Median circumferential segment length was 2 (1 -10) cms and maximal length was 3 (2 - 11) cms in both groups. Conclusions: BE is not an uncommon finding among Indian GERD patients. Age ≥45 years, history of eructation, presence of hiatus hernia are associated with SIM.

Affiliation

Department of Gastroenterology, and Department of Pathology, Seth G S Medical college & King Edward Memorial Hospital, Mumbai 400 012, India.

Journal Details

This article was published in the following journal.

Name: Journal of gastroenterology and hepatology
ISSN: 1440-1746
Pages:

Links

PubMed Articles [41731 Associated PubMed Articles listed on BioPortfolio]

Evaluation of Quantitative Digital Pathology in the Assessment of Barrett Esophagus-Associated Dysplasia.

Barrett esophagus (BE) is a precursor lesion that confers an increased risk of esophageal adenocarcinoma. Two issues confront the diagnosis of patients with BE: (1) sampling error at the time of endos...

Long segments of columnar-lined lower esophagus are not always metaplastic.

The presence of columnar epithelium in the esophagus is associated with two conditions: Barrett´s esophagus and heterotopic gastric mucosa. The former results from the metaplastic replacement of the ...

Common Questions About the Management of Gastroesophageal Reflux Disease.

Common questions that arise regarding treatment of gastroesophageal reflux disease (GERD) include which medications are most effective, when surgery may be indicated, which patients should be screened...

Screening and Surveillance for Barrett Esophagus.

Esophagus adenocarcinoma in a young patient with celiac disease; Is celiac disease a predisposing factor for esophagus adenocarcinoma as well as squamous cell carcinoma?

We report a 36-year-old female with longstanding oily diarrhea and new-onset dysphagia that was diagnosed as celiac disease and esophagus adenocarcinoma. Celiac is a multisystemic autoimmune disease a...

Clinical Trials [4122 Associated Clinical Trials listed on BioPortfolio]

DNA Changes as a Risk Factor for Barrett's Esophagus in Patients With Barrett's Esophagus, Gastroesophageal Reflux, or Gastrointestinal Bleeding

RATIONALE: A study that evaluates DNA changes and other disease-related health information in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding may h...

Studying Genes for Barrett's Esophagus in Brothers and Sisters

RATIONALE: Learning about how often heartburn and other risk factors occur in brothers and sisters and other family members of patients with Barrett's esophagus may help identify other ind...

The Study of Barrett's Esophagus: What Are the Factors of Progression

This trial is a multi-center clinical and endoscopic outcomes project involving a single large database of patients with Barrett's Esophagus (BE). The initial goal of this project is to de...

Familial Barrett's Esophagus

This is a multi-center study whose aim is to define the epidemiology and genetics of Barrett's esophagus and adenocarcinoma. The researchers have studied families affected with Barrett's e...

Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus

Patients with Barrett's Esophagus are known to have excessive distal esophageal acid exposure comparable to patients with erosive esophagitis. A significant proportion of patients with BE ...

Medical and Biotech [MESH] Definitions

A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.

The relating of causes to the effects they produce. Causes are termed necessary when they must always precede an effect and sufficient when they initiate or produce an effect. Any of several factors may be associated with the potential disease causation or outcome, including predisposing factors, enabling factors, precipitating factors, reinforcing factors, and risk factors.

Factors that can cause or prevent the outcome of interest, are not intermediate variables, and are not associated with the factor(s) under investigation. They give rise to situations in which the effects of two processes are not separated, or the contribution of causal factors cannot be separated, or the measure of the effect of exposure or risk is distorted because of its association with other factors influencing the outcome of the study.

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.


Advertisement
 

Relevant Topics

Barrett's Esophagus
Latest News Clinical Trials Research Drugs Reports Corporate
Barrett’s esophagus is a condition in which the tissue lining the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach—is replaced by tissue that is similar to the intestinal lining. This process is ca...

Gastroenterology
Latest News Clinical Trials Research Drugs Reports Corporate
Astroesophageal Reflux Disease (GERD) Barrett's Esophagus Celiac Disease Cholesterol Crohn's Disease Gastroenterology Hepatitis Hepatology Irritable Bowel Syndrome (IBS) Pancreatitis Peptic Ulcer Disease...

Advertisement
 

Searches Linking to this Article