Displacement Reaction Using Ibuprofen in a Mixture of Bioactive Imidazole Derivative and Bovine Serum Albumin-a Fluorescence Quenching Study.
Summary of "Displacement Reaction Using Ibuprofen in a Mixture of Bioactive Imidazole Derivative and Bovine Serum Albumin-a Fluorescence Quenching Study."
The mutual interaction of imidazole derivative (PIPP) with bovine serum albumin (BSA) was investigated using photoluminescent studies. The fluorescence quenching mechanism of BSA by PIPP was analyzed and the binding constant was calculated. The binding distance between PIPP and BSA was obtained based on the theory of Forester's non-radiation energy transfer. Displacement experiments were performed by using ibuprofen to identify PIPP binding site in BSA. The effect of some common ions on the binding constant between PIPP and BSA was also examined.
Affiliation
Department of Chemistry, Annamalai University, Annamalainagar, Tamilnadu, 608002, India, jtchalam2005@yahoo.co.in.
Journal Details
This article was published in the following journal.
Name: Journal of fluorescence
ISSN: 1573-4994
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21416257
- DOI: http://dx.doi.org/10.1007/s10895-011-0878-3
Medical and Biotech [MESH] Definitions
Hematoporphyrin Derivative
A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumors (HEMATOPORPHYRIN PHOTORADIATION). A purified component of this mixture is known as DIHEMATOPORPHYRIN ETHER.
Etomidate
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Aminoimidazole Carboxamide
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
Roxithromycin
Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.
Clotrimazole
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
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