Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia.
Summary of "Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia."
Introduction: Functional dyspepsia (FD) is a highly prevalent condition with a major impact on quality of life and high socio-economic and healthcare costs. To date, no treatment of established efficacy in FD is available. Acotiamide (Z-338 or YM443) is a new drug under development for the treatment of FD. Areas covered: Acotiamide is a gastroprokinetic drug that enhances acetylcholine release in the enteric nervous system via muscarinic receptor antagonism and acetycholinesterase inhibition. In conscious rats and dogs, acotiamide enhanced gastric contractility and accelerated delayed gastric emptying. Although in healthy volunteers acotiamide did not affect gastric emptying, gastric emptying and gastric accommodation were enhanced in FD. Acotiamide was evaluated in FD in several clinical studies in different countries and these are supportive of a symptomatic benefit. The beneficial effect is most consistently found with the 100 mg dose (three times a day) and primarily involves the postprandial distress syndrome symptoms of postprandial fullness, early satiety and upper abdominal bloating. The mechanism underlying the symptomatic benefit with acotiamide is not fully established but may involve enhanced gastric accommodation and increased gastric emptying. Expert opinion: Compared to placebo, no adverse events have been reported in the current short-term studies, while acotiamide seems efficacious for treating postprandial distress syndrome symptoms in FD patients.
Affiliation
University of Leuven, Translational Research Center for Gastrointestinal Disorders, Department of Pathophysiology, Herestraat 49, 0&N 1, bus 701, B-3000 Leuven, Belgium +3216344225 ; +3216344419 ; jan.tack@med.kuleuven.be.
Journal Details
This article was published in the following journal.
Name: Expert opinion on investigational drugs
ISSN: 1744-7658
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21417958
- DOI: http://dx.doi.org/10.1517/13543784.2011.562890
Medical and Biotech [MESH] Definitions
Cisapride
A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
Drug Therapy, Computer-assisted
Adjunctive computer programs in providing drug treatment to patients.
Drug Design
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Off-label Use
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
Dyspepsia
Impaired digestion, especially after eating.
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