P-Glycoprotein Inhibition; the Past, the Present and the Future.

Summary of "P-Glycoprotein Inhibition; the Past, the Present and the Future."

The multidrug resistant phenotype of cancer cells can often result from the over-production of a number of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp). These multi-drug efflux transporters expel administered anti-cancer drugs from the cancer cell, preventing sufficient intracellular drug accumulation and ultimately, drug efficacy. The co-administration of compounds that can impede the efflux of chemotherapeutic agents by these ABC-transporters can concomitantly modulate various cytochrome P450 (CYP450) enzymes, consequently impacting upon anti-cancer drug metabolism. This can further result in unfavourable drug-drug interactions and altered pharmacokinetic properties of the administered anti-cancer drugs with knock-on adverse cytotoxic side effects. This review will discuss some of the P-gp inhibitors designed and employed to date, as well as expressing our views of the shortcomings of their design strategy. We present a medicinal chemist's wish list for the paradigmatic P-gp inhibitor molecule and examine the possible future strategies that could be implemented to achieve its design.


Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK.

Journal Details

This article was published in the following journal.

Name: Current drug metabolism
ISSN: 1875-5453


DeepDyve research library

PubMed Articles [21356 Associated PubMed Articles listed on BioPortfolio]

Living in the Past, Present, and Future: Measuring Temporal Orientation with Language.

Temporal orientation refers to individual differences in the relative emphasis one places on the past, present, or future, and is related to academic, financial, and health outcomes. We propose and ev...

Image-guided brachytherapy in cervical cancer: past, present and future.

Temporal focus, temporal distance, and mind-wandering valence: Results from an experience sampling and an experimental study.

When mind-wandering, people may think about events that happened in the past, or events that may happen in the future. Using experience sampling, we first aimed to replicate the finding that future-or...

Feature: The IOC: past, present and future.

The past, present and future of genomic scans for selection.

Clinical Trials [2910 Associated Clinical Trials listed on BioPortfolio]

Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet

The purposes of this study are to investigate the duration of P-glycoprotein inhibition after oral administration of HM30181AK tablet in healthy male subject and proper dose of HM30181AK t...

Glycoprotein IIb/IIIa Inhibitors Versus Standard Therapy in Patients With Myocardial Infarction and No-reflow

Aim of the study is to examine the effects of glycoprotein IIb/IIIa inhibitors on reperfusion success assessed by cardiac magnetic resonance imaging in patients with myocardial infarction ...

Reactogenicity and Immunogenicity of Vaginal ZM96gp140

To determine the local (cervico-vaginal) and systemic (whole body) safety of vaginal immunisation with ZM96gp140 glycoprotein administered 9 times over a 3 week period.

PET Imaging With Tc-94m Sestamibi to Assess Resistance to Chemotherapy

Background: - Tc-94m sestamibi is a radioactive imaging drug approved by the Food and Drug Administration to help photograph and study bodily functions. - Tc-94m sestami...

Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

Cyclooxygenase-2 (COX-2) inhibitors have become a common analgesic treatment option for patients with arthritis. However, long-term treatment has been associated with increased cardiovascu...

Medical and Biotech [MESH] Definitions

A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.

A course or method of action selected to guide and determine present and future decisions.

Decisions for determining and guiding present and future objectives from among alternatives.

A course or method of action selected, usually by a government, from among alternatives to guide and determine present and future decisions.

Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.

Quick Search
DeepDyve research library

Relevant Topics

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Head and neck cancers
Cancer can occur in any of the tissues or organs in the head and neck. There are over 30 different places that cancer can develop in the head and neck area. Mouth cancers (oral cancers)  - Mouth cancer can develop on the lip, the tongue, the floor...

Searches Linking to this Article