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P-Glycoprotein Inhibition; the Past, the Present and the Future.

Summary of "P-Glycoprotein Inhibition; the Past, the Present and the Future."

The multidrug resistant phenotype of cancer cells can often result from the over-production of a number of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp). These multi-drug efflux transporters expel administered anti-cancer drugs from the cancer cell, preventing sufficient intracellular drug accumulation and ultimately, drug efficacy. The co-administration of compounds that can impede the efflux of chemotherapeutic agents by these ABC-transporters can concomitantly modulate various cytochrome P450 (CYP450) enzymes, consequently impacting upon anti-cancer drug metabolism. This can further result in unfavourable drug-drug interactions and altered pharmacokinetic properties of the administered anti-cancer drugs with knock-on adverse cytotoxic side effects. This review will discuss some of the P-gp inhibitors designed and employed to date, as well as expressing our views of the shortcomings of their design strategy. We present a medicinal chemist's wish list for the paradigmatic P-gp inhibitor molecule and examine the possible future strategies that could be implemented to achieve its design.

Affiliation

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK. richard.darby@ndcls.ox.ac.uk.

Journal Details

This article was published in the following journal.

Name: Current drug metabolism
ISSN: 1875-5453
Pages:

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