Advertisement

Topics

Intramolecular Michael addition reaction for the synthesis of benzylbutyrolactones.

Summary of "Intramolecular Michael addition reaction for the synthesis of benzylbutyrolactones."

A convenient synthesis of benzyl-gamma-butyrolactone derivatives via intramolecular Michael addition reaction of nitro-substituted aryl allyl beta-ketocarboxylates is reported. The method features simple operation, mild reaction conditions and high efficiency.

Affiliation

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P. R. China.

Journal Details

This article was published in the following journal.

Name: Organic & biomolecular chemistry
ISSN: 1477-0539
Pages: 3207-10

Links

DeepDyve research library

PubMed Articles [16288 Associated PubMed Articles listed on BioPortfolio]

Metal-Catalyzed Asymmetric Michael Addition in Natural Product Synthesis.

Asymmetric catalysis for chiral compound synthesis is a rapidly growing field in modern organic chemistry. Asymmetric catalytic processes have been indispensable for the synthesis of enantioselective ...

Asymmetric Synthesis of Octahydroindoles via a Domino Robinson Annulation/5-Endo Intramolecular Aza-Michael Reaction.

A straightforward two-step asymmetric synthesis of octahydroindoles has been developed based on two complimentary strategies: (i) an organocatalyzed Michael reaction followed by a tandem Robinson-aza-...

Bioinspired Total Synthesis of Homodimericin A.

Homodimericin A is a remarkable fungal metabolite, and a highly oxygenated and racemic unsaturated polyketide. It poses a significant synthetic challenge due to its sterically demanding central cage-l...

In Situ-Forming Polyamidoamine Dendrimer Hydrogels with Tunable Properties Prepared via Aza-Michael Addition Reaction.

In this work, we describe synthesis and characterization of novel in situ-forming polyamidoamine (PAMAM) dendrimer hydrogels (DHs) with tunable properties prepared via highly efficient aza-Michael add...

Facile synthesis of cyanofurans via Michael-addition/cyclization of ene-yne-ketones with trimethylsilyl cyanide.

We have developed a Michael-addition/cyclization procedure between ene-yne-ketones and TMSCN under metal-free conditions. A wide range of cyanofurans was delivered in high yields, which could be furth...

Clinical Trials [1739 Associated Clinical Trials listed on BioPortfolio]

Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates

The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recre...

A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis

Cholesterol is the precursor of glucocorticoids, mineralocorticoids and sex steroids. Both adrenal and non-adrenal (ovarian + testicular) all steroid hormones are primarily synthesized usi...

Effect of Nutrition on Muscle Protein Synthesis

The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities. We hypothesize that m...

Montelukast in ENL Reaction

Objective of the trial is to assess the safety and efficacy of Montelukast in treatment of Erythema Nodosum leprosum (ENL) reaction in multibacillary leprosy patients either in combination...

Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis

The primary purpose of the study is to evaluate the therapeutic efficacy and safety of cholic acid in subjects with identified inborn errors of bile acid synthesis.

Medical and Biotech [MESH] Definitions

A photoprotein isolated from the bioluminescent jellyfish Aequorea. It emits visible light by an intramolecular reaction when a trace amount of calcium ion is added. The light-emitting moiety in the bioluminescence reaction is believed to be 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (AF-350).

A reaction characterized by a violet color upon the addition of copper sulfate to all compounds with two amide or peptide bonds linked directly or through an intermediate carbon atom. Used in the detection and estimation of proteins and peptides having more than two amino acids.

An ATP-dependent enzyme that catalyzes the addition of ADP to alpha-D-glucose 1-phosphate to form ADP-glucose and diphosphate. The reaction is the rate-limiting reaction in prokaryotic GLYCOGEN and plant STARCH biosynthesis.

An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.

A technique for detecting short-lived reactive FREE RADICALS in biological systems by providing a nitrone or nitrose compound for an addition reaction to occur which produces an ELECTRON SPIN RESONANCE SPECTROSCOPY-detectable aminoxyl radical. In spin trapping, the compound trapping the radical is called the spin trap and the addition product of the radical is identified as the spin adduct. (Free Rad Res Comm 1990;9(3-6):163)

Quick Search
Advertisement
 


DeepDyve research library

Searches Linking to this Article