Advertisement

Topics

Toxicology and risk assessment of 5-Hydroxymethylfurfural in food.

06:00 EDT 5th April 2011 | BioPortfolio

Summary of "Toxicology and risk assessment of 5-Hydroxymethylfurfural in food."

5-Hydroxymethylfurfural (5-HMF) as a product of the Maillard reaction is found in many foods. Estimated intakes range between 4 and 30 mg per person and day, while an intake of up to 350 mg can result from, e.g., beverages made from dried plums. In vitro genotoxicity was positive when the metabolic preconditions for the formation of the reactive metabolite 5-sulphoxymethylfurfural were met. However, so far in vivo genotoxicity was negative. Results obtained in short-term model studies for 5-HMF on the induction of neoplastic changes in the intestinal tract were negative or cannot be reliably interpreted as "carcinogenic". In the only long-term carcinogenicity study in rats and mice no tumours or their precursory stages were induced by 5-HMF aside from liver adenomas in female mice, the relevance of which must be viewed as doubtful. Hence, no relevance for humans concerning carcinogenic and genotoxic effects can be derived. The remaining toxic potential is rather low. Various animal experiments reveal that no adverse effect levels are in the range of 80-100 mg/kg body weight and day. Safety margins are generally sufficient. However, 5-HMF exposure resulting from caramel colours used as food additives should be further evaluated.

Affiliation

Department of Food Safety, Federal Institute for Risk Assessment, Germany.

Journal Details

This article was published in the following journal.

Name: Molecular nutrition & food research
ISSN: 1613-4133
Pages:

Links

DeepDyve research library

PubMed Articles [24297 Associated PubMed Articles listed on BioPortfolio]

Corrigendum to "Risk assessment in combustion toxicology: Should carbon dioxide be recognized as a modifier of toxicity or separate toxicological entity?" Toxicol. Lett. 262 (2016) 142-152.

Food Additives: A special issue of the journal Food and Chemical Toxicology.

Risk assessment of patulin intake through apple-based food by infants and preschool children in Serbia.

This study reports for the first time in Serbia the occurrence of patulin in apple-based food and the risk assessment associated with patulin intake by infants and preschool children. In total, 214 sa...

Do we know what we eat?: Perceptions regarding food risks in Catalonia, Spain.

This article describes and analyzes social perceptions regarding food risks in Catalonia (Spain). In particular it uses the narratives of informants to determine which foods are perceived as dangerous...

Assessing food allergy risks from residual peanut protein in highly refined vegetable oil.

Refined vegetable oils including refined peanut oil are widely used in foods. Due to shared production processes, refined non-peanut vegetable oils can contain residual peanut proteins. We estimated t...

Clinical Trials [6144 Associated Clinical Trials listed on BioPortfolio]

Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers

The purpose of this research study is to determine whether eating a fast food meal (high in saturated fat) will result in greater increases in inflammatory markers than eating a meal with ...

A Prospective Study for the Assessment of Recurrence Risk in Stage II Colon Cancer Patients Using ColoPrint

This prospective study will address the feasibility and quality assurance of the prognostic profile ColoPrint in clinical practice. ColoPrint risk assessment results will be compared to th...

Improving The Safety And Nutritional Adequacy Of The Home Food Supply Of Elderly Recipients Of Home Delivered Meals

Rutgers University will partner with the Meals on Wheels America (MOWA) and affiliated agencies in five states to conduct a study designed to improve food safety nutrition and emergency pr...

The Association Between Food Insecurity and Incident Type 2 Diabetes in Canada: A Population-based Cohort Study

A pervasive and persistent finding is the health disadvantage experienced by those in food insecure households. While clear associations have been identified between food insecurity and di...

A Device for Screening of Fall Risk in the Elderly

This study evaluates the screening accuracy of a device (OAK) in assessing fall risk in the elderly, compared to the assessment provided by the Algorithm for Fall Risk Assessment of the Ce...

Medical and Biotech [MESH] Definitions

The application of TOXICOLOGY knowledge to questions of law.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Prospective risk assessment tool aimed at identifying potential risks and their impact in healthcare settings.

Dynamic and kinetic mechanisms of exogenous chemical and drug ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and TOXICOLOGY as a function of dosage, and rate of METABOLISM. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. ADME and ADMET are short-hand abbreviations for absorption, distribution, metabolism, elimination and toxicology.

Multidisciplinary field focusing on prevention of infectious diseases and patient safety during international TRAVEL. Key element of the pretravel physician's visit is a health risk assessment.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Food
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Hepatology
Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...


Searches Linking to this Article