Toxicology and risk assessment of 5-Hydroxymethylfurfural in food.

06:00 EDT 5th April 2011 | BioPortfolio

Summary of "Toxicology and risk assessment of 5-Hydroxymethylfurfural in food."

5-Hydroxymethylfurfural (5-HMF) as a product of the Maillard reaction is found in many foods. Estimated intakes range between 4 and 30 mg per person and day, while an intake of up to 350 mg can result from, e.g., beverages made from dried plums. In vitro genotoxicity was positive when the metabolic preconditions for the formation of the reactive metabolite 5-sulphoxymethylfurfural were met. However, so far in vivo genotoxicity was negative. Results obtained in short-term model studies for 5-HMF on the induction of neoplastic changes in the intestinal tract were negative or cannot be reliably interpreted as "carcinogenic". In the only long-term carcinogenicity study in rats and mice no tumours or their precursory stages were induced by 5-HMF aside from liver adenomas in female mice, the relevance of which must be viewed as doubtful. Hence, no relevance for humans concerning carcinogenic and genotoxic effects can be derived. The remaining toxic potential is rather low. Various animal experiments reveal that no adverse effect levels are in the range of 80-100 mg/kg body weight and day. Safety margins are generally sufficient. However, 5-HMF exposure resulting from caramel colours used as food additives should be further evaluated.


Department of Food Safety, Federal Institute for Risk Assessment, Germany.

Journal Details

This article was published in the following journal.

Name: Molecular nutrition & food research
ISSN: 1613-4133


DeepDyve research library

PubMed Articles [22613 Associated PubMed Articles listed on BioPortfolio]

Current issues and perspectives in food safety and risk assessment.

In this review, current issues and opportunities in food safety assessment are discussed. Food safety is considered an essential element inherent in global food security. Hazard characterization is pi...

Risk Assessment of Pesticide Residues in Dietary Intake of Celery in China.

Residue risk assessment of pesticides in celery was conducted to provide a scientific basis for agricultural regulation policies and working procedures.

Mode of action based risk assessment of the botanical food-borne alkenylbenzene apiol from parsley using physiologically based kinetic (PBK) modelling and read-across from safrole.

The present study developed physiologically-based kinetic (PBK) models for the alkenylbenzene apiol in order to facilitate risk assessment based on read-across from the related alkenylbenzene safrole....

Uncertainties in human health risk assessment of environmental contaminants: A review and perspective.

Addressing uncertainties in human health risk assessment is a critical issue when evaluating the effects of contaminants on public health. A range of uncertainties exist through the source-to-outcome ...

Quantitative risk assessment on the dietary exposure of Finnish children and adults to nitrite.

Nitrite intake from consumption of cured meat and tap water was estimated for Finnish children of 1, 3 and 6 years as well as Finnish adults of 25 to 74 years. Nitrite content in the foods was measu...

Clinical Trials [4875 Associated Clinical Trials listed on BioPortfolio]

Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers

The purpose of this research study is to determine whether eating a fast food meal (high in saturated fat) will result in greater increases in inflammatory markers than eating a meal with ...

A Prospective Study for the Assessment of Recurrence Risk in Stage II Colon Cancer Patients Using ColoPrint

This prospective study will address the feasibility and quality assurance of the prognostic profile ColoPrint in clinical practice. ColoPrint risk assessment results will be compared to th...

Improving The Safety And Nutritional Adequacy Of The Home Food Supply Of Elderly Recipients Of Home Delivered Meals

Rutgers University will partner with the Meals on Wheels America (MOWA) and affiliated agencies in five states to conduct a study designed to improve food safety nutrition and emergency pr...

A Device for Screening of Fall Risk in the Elderly

This study evaluates the screening accuracy of a device (OAK) in assessing fall risk in the elderly, compared to the assessment provided by the Algorithm for Fall Risk Assessment of the Ce...

Primary Care Audit of Global Risk Management

1. Assessing the perception of Canadian Primary Care Physicians towards global cardiovascular risk assessment. 2. Correlating physician perceptions to actual practice data, gathere...

Medical and Biotech [MESH] Definitions

The application of TOXICOLOGY knowledge to questions of law.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Multidisciplinary field focusing on prevention of infectious diseases and patient safety during international TRAVEL. Key element of the pretravel physician's visit is a health risk assessment.

The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))

Dynamic and kinetic mechanisms of exogenous chemical and drug ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and TOXICOLOGY as a function of dosage, and rate of METABOLISM. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. ADME and ADMET are short-hand abbreviations for absorption, distribution, metabolism, elimination and toxicology.

Quick Search

DeepDyve research library

Relevant Topics

Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

Searches Linking to this Article