Toxicology and risk assessment of 5-Hydroxymethylfurfural in food.

20:08 EST 20th December 2014 | BioPortfolio

Summary of "Toxicology and risk assessment of 5-Hydroxymethylfurfural in food."

5-Hydroxymethylfurfural (5-HMF) as a product of the Maillard reaction is found in many foods. Estimated intakes range between 4 and 30 mg per person and day, while an intake of up to 350 mg can result from, e.g., beverages made from dried plums. In vitro genotoxicity was positive when the metabolic preconditions for the formation of the reactive metabolite 5-sulphoxymethylfurfural were met. However, so far in vivo genotoxicity was negative. Results obtained in short-term model studies for 5-HMF on the induction of neoplastic changes in the intestinal tract were negative or cannot be reliably interpreted as "carcinogenic". In the only long-term carcinogenicity study in rats and mice no tumours or their precursory stages were induced by 5-HMF aside from liver adenomas in female mice, the relevance of which must be viewed as doubtful. Hence, no relevance for humans concerning carcinogenic and genotoxic effects can be derived. The remaining toxic potential is rather low. Various animal experiments reveal that no adverse effect levels are in the range of 80-100 mg/kg body weight and day. Safety margins are generally sufficient. However, 5-HMF exposure resulting from caramel colours used as food additives should be further evaluated.

Affiliation

Department of Food Safety, Federal Institute for Risk Assessment, Germany.

Journal Details

This article was published in the following journal.

Name: Molecular nutrition & food research
ISSN: 1613-4133
Pages:

Links

PubMed Articles [20847 Associated PubMed Articles listed on BioPortfolio]

Microbial risk assessment of Vibrio spp. in seafood products in Mexico.

Food-borne diseases are among the major public health problems that currently exist. Microbiological risk assessment is a process used to evaluate the hidden hazards in food, the likelihood of exposur...

Applicability and feasibility of systematic review for performing evidence-based risk assessment in food and feed safety.

Abstract Food and feed safety risk assessment uses multi-parameter models to evaluate the likelihood of adverse events associated with exposure to hazards in human health, plant health, animal health,...

Adaptation of the ToxRTool to assess the reliability of toxicology studies conducted with genetically modified crops and implications for future safety testing.

Abstract To determine the reliability of food safety studies carried out in rodents with genetically modified (GM) crops, a Food Safety Study Reliability Tool (FSSRTool) was adapted from the European ...

Risk Control and Food Safety: Proceedings of the 11th UJNR International Symposium on Toxic Microorganisms, March 4-9, 2012, Tokyo, Japan.

Mind the gap: Concerns using endpoints from endocrine screening assays in risk assessment.

Endocrine screening assays not only provide mechanistic information on the potential of a substance to interact with the endocrine system, but also data potentially relevant for risk assessment. Howev...

Clinical Trials [3574 Associated Clinical Trials listed on BioPortfolio]

Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers

The purpose of this research study is to determine whether eating a fast food meal (high in saturated fat) will result in greater increases in inflammatory markers than eating a meal with ...

A Prospective Study for the Assessment of Recurrence Risk in Stage II Colon Cancer Patients Using ColoPrint

This prospective study will address the feasibility and quality assurance of the prognostic profile ColoPrint in clinical practice. ColoPrint risk assessment results will be compared to th...

Primary Care Audit of Global Risk Management

1. Assessing the perception of Canadian Primary Care Physicians towards global cardiovascular risk assessment. 2. Correlating physician perceptions to actual practice data, gathere...

Effect of Type 2 Diabetes Genetic Risk Information on Health Behaviors and Outcomes

The primary objective of the study is to assess the clinical utility of a genetic test for Type 2 diabetes risk in combination with standardized risk assessment compared with standardized ...

Risk Assessment and Treat Compliance in Hypertension Education Trial

The RATCHET study assesses if patient knowledge of estimated cardiovascular risk at current and recommended target blood pressure levels improves compliance in the management of hypertensi...

Medical and Biotech [MESH] Definitions

The application of TOXICOLOGY knowledge to questions of law.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Multidisciplinary field focusing on prevention of infectious diseases and patient safety during international TRAVEL. Key element of the pretravel physician's visit is a health risk assessment.

The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))

Dynamic and kinetic mechanisms of exogenous chemical and drug ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and TOXICOLOGY as a function of dosage, and rate of METABOLISM. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. ADME and ADMET are short-hand abbreviations for absorption, distribution, metabolism, elimination and toxicology.

Search BioPortfolio:
Loading