Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP(+): The involvement of PI3K/Akt pathway activation.
Summary of "Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP(+): The involvement of PI3K/Akt pathway activation."
Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), which is an active component of the rhizome extract from polygonum multiflorum, shows potent antioxidant properties. In this paper, the neuroprotective effects of TSG on 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in PC12 cells were investigated. Pretreatment with TSG markedly attenuated MPP(+)-induced loss of cell viability and release of lactate dehydrogenase (LDH), and reduced MPP(+)-induced apoptotic cell death in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated by the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway since TSG failed to rescue cells from MPP(+) injury in the presence of the PI3K inhibitor, LY294002. These results indicate that TSG affords a significant neuroprotective effect against MPP(+)-induced damage and apoptosis in PC12 cells. The PI3K/Akt signaling pathway might be involved in the TSG-mediated anti-apoptotic effects.
Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, China.
This article was published in the following journal.
Name: Toxicology letters
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21237255
- DOI: http://dx.doi.org/10.1016/j.toxlet.2011.01.001
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