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Cholesterol Efflux Capacity and Atherosclerosis.

06:00 EDT 15th April 2011 | BioPortfolio

Summary of "Cholesterol Efflux Capacity and Atherosclerosis."

To the Editor: Khera et al. (Jan. 13 issue)(1) report that cholesterol efflux from macrophages was a marginally better predictor of coronary artery disease than high-density lipoprotein (HDL) cholesterol (odds ratio, 0.75 vs. 0.85). They feel that the heterogeneity in particle size, charge, and protein composition of HDL make HDL cholesterol levels a poor surrogate for cholesterol efflux capacity and reduce the predictive value of HDL cholesterol for carotid intima-media thickness and coronary artery disease. Of all the HDL particles, HDL(2) plasma levels have shown the greatest hazard reduction for incident coronary heart disease.(2) Furthermore, macrophage cholesterol efflux positively . . .

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Journal Details

This article was published in the following journal.

Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 1472-1475

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Medical and Biotech [MESH] Definitions

Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

An ATP binding cassette transporter, sub-family G protein that functions as a high capacity UREA exporter, transporter of STEROLS, and in the absorption and efflux of many drugs. Its efflux activity for ANTINEOPLASTIC AGENTS contributes to DRUG RESISTANCE. It functions as a homodimer and is expressed by cells in a variety of organs, as well as by NEOPLASTIC STEM CELLS.

Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.

Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.

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