Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris - A multicenter, randomised, double-blind controlled study.
Summary of "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris - A multicenter, randomised, double-blind controlled study."
Background:â€‚ Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris. Objectives:â€‚ To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0.1%-BPO 2.5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris. Methods:â€‚ 378 subjects were randomised in a double-blind controlled trial to receive once daily lymecycline with either A/BPO or vehicle for 12 weeks. Evaluations included percentage changes from baseline in lesion counts, success rate (subjects "clear" or "almost clear"), skin tolerability, adverse events and patients' satisfaction. Results:â€‚ The median percent reduction from baseline in total lesion counts at week 12 was significantly higher (p<0.001) in the lymecycline with A/BPO group (-74.1%) than in the lymecycline with vehicle group (-56.8%). The success rate was significantly higher (47.6%versus 33.7%, p=0.002) in subjects treated with lymecycline and A/BPO. Both inflammatory and non-inflammatory lesions were significantly reduced at week 12 (both p<0.001) with a rapid onset of action from week 2 for non-inflammatory lesions (p<0.001) and week 4 for inflammatory lesions (p=0.005). The A/BPO and lymecycline combination was well-tolerated. The proportion of satisfied and very satisfied subjects was similar in both groups, but the number in the A/BPO group who were "very satisfied" was significantly greater (p=0.031). Conclusions:â€‚ These results demonstrated the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris.
HÃ´pital Hotel Dieu, Department of Dermato-Oncology, Nantes, France Department of Dermatology, Goethe-University Hospital, Frankfurt am Main, Germany UNIFESP - Universidade Federal de SÃ£o Paulo, SÃ£o Paulo, Brazil Department of Dermatology, JuÃ¡rez Hospi
This article was published in the following journal.
Name: The British journal of dermatology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21495995
- DOI: http://dx.doi.org/10.1111/j.1365-2133.2011.10374.x
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Medical and Biotech [MESH] Definitions
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