The Clinical Analysis of Paclitaxel at Two Dose Levels plus Carboplatin as the First-line Treatment in Advanced Non-small Cell Lung Cancer.
Summary of "The Clinical Analysis of Paclitaxel at Two Dose Levels plus Carboplatin as the First-line Treatment in Advanced Non-small Cell Lung Cancer."
BACKGROUND:
The combination of pacilitaxel and carboplatin has become a widely used regimen in first-line therapy of advanced NSCLC. The aim of this study is to compare the efficacy and safety of paclitaxel plus carboplatin at two dose levels in the first-line treatment of advanced NSCLC patients.
METHODS:
From Dec 2006 to Jun 2008, 63 patients (ECOG 0-1) with advanced NSCLC were administered with paclitaxel 175 mg/m² (42 patients) plus carboplatin (AUC 5) or paclitaxel 200 mg/m² (21 patients) plus carboplatin (AUC 5), 3-4 weeks/cycle.
RESULTS:
The objective response rate of paclitaxel 175 mg/m² group and paclitaxel 200 mg/m² group was 28.57% vs 33.33% (P=0.698); median time to progression were 6.7 months vs 7.0 months (P=0.561); median overall survival time were 18.7 months vs 19.0 months (P=0.255); one and two-year survival rate were 61.9% vs 66.7% (P=0.711) and 31.0% vs 33.3% (P=0.852), respectively. Neutropenia 3/4 grade was 61.9% vs 33.3% in paclitaxel 200 mg/m² group and paclitaxel 175 mg/m² group (P=0.031).
CONCLUSIONS:
175 mg/m² dose paclitaxel causes less neutropenia than higher dose paclitaxel. Response rate, survival rate, time to progression and survival time are not statistically significant in two groups.
Affiliation
Department of Pulmonary Medicine, Shanghai Chest hospital, Shanghai Jiaotong University, Shanghai 200030, China.
Journal Details
This article was published in the following journal.
Name: Zhongguo fei ai za zhi = Chinese journal of lung cancer
ISSN: 1999-6187
Pages: 323-328
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21496430
- DOI: http://dx.doi.org/10.3779/j.issn.1009-3419.2011.04.04
Medical and Biotech [MESH] Definitions
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Lethal Dose 50
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Carboplatin
An organoplatinum compound that possesses antineoplastic activity.
Maximum Tolerated Dose
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
Dose Fractionation
Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.
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