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(68)Ga-DOTA-NOC PET/CT Imaging of Neuroendocrine Tumors: Comparison with (111)In-DTPA-Octreotide (OctreoScan(R)).

06:00 EDT 24th July 2010 | BioPortfolio

Summary of "(68)Ga-DOTA-NOC PET/CT Imaging of Neuroendocrine Tumors: Comparison with (111)In-DTPA-Octreotide (OctreoScan(R))."


PURPOSE:
Recent data have indicated that (68)Ga-DOTA-NOC positron emission tomography/X-ray computed tomography (PET/CT) may yield improved images in a shorter acquisition protocol than (111)In-DTPA-octreotide (OctreoScan(R), OCT). Therefore, we performed a prospective comparison of (68)Ga-DOTA-NOC and OCT for the detection of neuroendocrine tumors (NETs).
METHODS:
Nineteen patients (eight carcinoid, nine pancreatic NETs, and two NE carcinoma of unknown origin) with previous positive OCT scans underwent (68)Ga-DOTA-NOC PET/CT and OCT single-photon emission computed tomography imaging for staging or follow-up. Findings were compared by region and verified with conventional imaging.
RESULTS:
All images of both modalities demonstrated focal uptake, often at multiple sites. (68)Ga-DOTA-NOC images were clearer than OCT images, facilitating interpretation. Similar foci were identified with both modalities in 41 regions, with additional foci on (68)Ga-DOTA-NOC in 21 and on OCT in 15 regions. CT, magnetic resonance imaging, or ultrasound confirmed the concordant findings in 31 of 41 regions and findings seen with (68)Ga-DOTA-NOC only in 15 of 21 regions. Findings seen with OCT only were less clear and were only confirmed in 4 of 15 regions. (68)Ga-DOTA-NOC had impact on staging in four patients and on management in three patients.
CONCLUSIONS:
Although (68)Ga-DOTA-NOC and OCT images were similar, in this study, (68)Ga-DOTA-NOC demonstrated more true positive tumor foci and was better tolerated by patients. This direct comparison supports replacement of OCT with (68)Ga-DOTA-NOC-PET/CT in the evaluation of NETs.

Affiliation

Department of Medical Biophysics and Nuclear Medicine, Hadassah-Hebrew University Medical Center, P.O. Box 12000, Jerusalem, 91120, Israel, yodphat@hadassah.org.il.

Journal Details

This article was published in the following journal.

Name: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
ISSN: 1860-2002
Pages:

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Medical and Biotech [MESH] Definitions

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

A 38-kDa integral membrane glycoprotein of the presynaptic vesicles in neuron and neuroendocrine cells. It is expressed by a variety of normal and neoplastic neuroendocrine cells and is therefore used as an immunocytochemical marker for neuroendocrine differentiation in various tumors. In ALZHEIMER DISEASE and other dementing disorders, there is an important synapse loss due in part to a decrease of synaptophysin in the presynaptic vesicles.

The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

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