Cartography of human diaphragmatic innervation: preliminary data.
Summary of "Cartography of human diaphragmatic innervation: preliminary data."
In humans, anatomy indicates that the phrenic nerve mainly arises from the C4 cervical root, with variable C3 and C5 contributions. How this translates into functional innervation is unknown. The diaphragm response to electrical stimulation of C3, C4 and C5 was described in three patients undergoing surgical laryngeal reinnervation with an upper phrenic root (surface chest electrodes at anterior, lateral and posterior sites; oesophageal and gastric pressures (Pes and Pga) to derive transdiaphragmatic pressure (Pdi)). Anatomically, the phrenic nerve predominantly originated from C4. Phrenic stimulation elicited motor responses at the three sites in the three patients, as did C4 stimulation. It produced Pdi values of 9, 11, and 14cmH(2)O in the three patients, respectively, vs. 9, 9, and 7cmH(2)O for C4. C3 stimulation produced modest Pdi responses, whereas C5 stimulation could produce Pdi responses close to those observed with C4 stimulation. These singular observations confirm the dominance of C4 in diaphragm innervation but suggest than C5 can be of importance.
Rouen University Hospital, Department of Physiology, 76031 Rouen Cedex, France. firstname.lastname@example.org
This article was published in the following journal.
Name: Respiratory physiology & neurobiology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21073984
- DOI: http://dx.doi.org/10.1016/j.resp.2010.11.003
Medical and Biotech [MESH] Definitions
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Hernia, Diaphragmatic, Traumatic
The type of DIAPHRAGMATIC HERNIA caused by TRAUMA or injury, usually to the ABDOMEN.
A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.
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