Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats.

13:51 EDT 6th July 2015 | BioPortfolio

Summary of "Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats."

Dopaminergic stabilizers may be conceptualized as drugs with normalizing effects on dopamine-mediated behaviours and neurochemical events. (S)-(-)-OSU6162 (OSU6162) and ACR16 are two structurally related compounds ascribed such properties, principally because of their stabilizing effects on motor activity in rodents. Reports in the literature indicate possible partial D2 receptor agonist effects using various in vitro systems. This study aimed to measure D2 receptor antagonist and agonist effects of OSU6162 and ACR16 in vivo. To address this, we have studied the effects of both compounds on prolactin secretion in drug-naive and dopamine-depleted rats; dopamine depletion was induced by pretreatment with reserpine plus α-methyl-
DL:
-p-tyrosine. We find that OSU6162 and ACR16 both stimulate prolactin secretion in drug-naive rats with OSU6162 being considerably more potent and efficacious. Both compounds show a non-significant trend towards reversal of the increased secretion caused by dopamine depletion, whereas the D2 receptor antagonist haloperidol further increased prolactin secretion. Thus, this study suggests that OSU6162 and ACR16 act as D2 receptor antagonists under normal conditions in vivo, possibly with minor agonist effects in a state of dopamine depletion.

Affiliation

Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Box 432, 405 30, Gothenburg, Sweden, rungjp@gmail.com.

Journal Details

This article was published in the following journal.

Name: Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Pages:

Links

PubMed Articles [19888 Associated PubMed Articles listed on BioPortfolio]

Effects of prolactin and lactation on A15 dopamine neurons in the rostral preoptic area of female mice.

There are several distinct populations of dopamine neurons in the hypothalamus. Some of these, such as the A12 tuberoinfundibular dopamine neurons and the A14 periventricular dopamine neurons are know...

New insights in prolactin: pathological implications.

Prolactin is a hormone that is mainly secreted by lactotroph cells of the anterior pituitary gland, and is involved in many biological processes including lactation and reproduction. Animal models hav...

Dopamine Modulates Insulin Release and Is Involved in the Survival of Rat Pancreatic Beta Cells.

The local synthesis of dopamine and its effects on insulin release have been described in isolated islets. Thus, it may be accepted that dopamine exerts an auto-paracrine regulation of insulin secreti...

Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system.

Vulnerability to drug addiction depends upon the interactions between the biological make-up of the individual, the environment, and age. These interactions are complex and difficult to tease apart. S...

Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment: A Randomized, Open-Label Study.

Extrapyramidal symptoms (EPS) are common adverse effects of antipsychotic treatment. This study examined the effects of the traditional Japanese herbal medicine (kampo) shakuyaku-kanzo-to on EPS durin...

Clinical Trials [2364 Associated Clinical Trials listed on BioPortfolio]

A Study of ACR16 for the Treatment of Patients With Huntington's Disease

The purpose of this trial is to compare three doses of ACR16 and determine if ACR16 is effective and safe in the symptomatic treatment of Huntington's Disease.

A Study of Treatment With ACR16 in Patients With Huntington's Disease

The purpose of this study is to determine if ACR16 is effective and safe in the symptomatic treatment of Huntington's disease.

An Open-Label Study of Naltrexone in Adults With Attention Deficit Hyperactivity Disorder.

The primary aim of this study is to assess whether naltrexone as a monotherapy is effective in treating ADHD in adults. Medications that increase dopamine are often effective in treating ...

Recombinant Human Prolactin for Lactation Induction

The purpose of the study is to assess the safety and determine the effects of the hormone prolactin on lactation (breast milk production).

Recombinant Human Prolactin for Lactation Induction

The purpose of the study is to assess the safety and determine the effects of the hormone prolactin on lactation (breast milk production).

Medical and Biotech [MESH] Definitions

A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.

A number of peptides with inhibitory activities on PROLACTIN release have been isolated from the HYPOTHALAMUS, the peripheral nervous system, and the gut. These include SOMATOSTATIN, and peptides derived from POMC and precursor for VASOPRESSIN-ASSOCIATED NEUROPHYSIN. Biogenic amine DOPAMINE is also a potent PIF.


Advertisement
 

Relevant Topics

Drug Discovery
Latest News Clinical Trials Research Drugs Reports Corporate
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Pharmacy
Latest News Clinical Trials Research Drugs Reports Corporate
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Advertisement
 

Searches Linking to this Article