Tumescent Liposuction: Partitioning of Lidocaine at a Lower Dose (252 mg/l).
Summary of "Tumescent Liposuction: Partitioning of Lidocaine at a Lower Dose (252 mg/l)."
Background: The popularity of large-volume liposuction and the toxicity of lidocaine have led to a reduction of lidocaine dosage in tumescent liposuction. We have gradually reduced the concentration of lidocaine from 500 to 252 mg/l over the past decade. Objective: To evaluate the partitioning and the recovery of lidocaine at a lower concentration in tumescent liposuction. Methods: 10 consecutive patients' aspirate samples were analysed for the lidocaine concentration in the fat and the fluid component, the percentage of injected lidocaine removed by aspiration and its partition coefficient in fat versus fluid. Results: 7.5% of the injected lidocaine was removed; its partition coefficient was 0.21. Conclusion: 7.5% of the total lidocaine was aspirated in tumescent liposuction. The fat uptake of lidocaine was lower than in previous reports, which was of particular interest for future studies on lidocaine toxicity for the safety of the patients undergoing tumescent liposuction.
Affiliation
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal Details
This article was published in the following journal.
Name: Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21540572
- DOI: http://dx.doi.org/10.1159/000327382
Medical and Biotech [MESH] Definitions
Lethal Dose 50
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Maximum Tolerated Dose
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
Dose Fractionation
Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.
Cell Compartmentation
A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc.
Radiotherapy, Conformal
Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.
PubMed Articles
Safety of Tumescent Liposuction under Local Anesthesia in a Series of 4,380 Patients.
Background: Liposuction is increasingly performed under local anesthesia and in an outpatient setting. The term 'tumescent liposuction' has been used in the literature in patients receiving other form...
Abdominoplasty with thorough concurrent circumferential abdominal tumescent liposuction.
Abdominoplasty, the removal of excess skin combined with muscle plication of a patient's abdominal region, can yield pleasing postoperative results alone, but adding significant concurrent circumferen...
Outcomes after Tumescence Technique versus Electrocautery Mastectomy.
BACKGROUND: Tumescence is the injection of local anesthetic and crystalloid into the subcutaneous tissue to establish a bloodless plane for surgical dissection. The aim of our study was to evaluate ou...
Although the coadministration of lidocaine with propranolol interferes with the metabolic profile (pharmacokinetics), its pharmacodynamics is still unclear. In this report, we investigate whether prop...
Propranolol elicits cutaneous analgesia against skin nociceptive stimuli in rats.
The purpose of this study was to investigate the cutaneous analgesic effect of propranolol and compare with a local anesthetic lidocaine. The potencies and equipotent doses were determined for infiltr...
Clinical Trials
Tumescent Lidocaine Maximum Safe mg/kg Dosage
This pharmacokinetic clinical trial is a dose ranging study of lidocaine in tumescent local anesthesia. The goal is to understand the absorption pharmacokinetic of tumescent lidocaine and...
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0.5%...
Lidocaine and Pain Management in First Trimester Abortions
The purpose of this study is to examine the effect of lidocaine (a numbing medication) inside the uterus on patient pain during an early abortion, compared to the paracervical block (lidoc...
Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
There is some controversy in the medical literature regarding the effectiveness of topical lidocaine in children as an adjuvant drug to upper gastrointestinal endoscopy. In children, deep...
Mechanisms Defending Fat Mass in Humans After Lipectomy
Liposuction surgery is common, yet animal and limited human data suggest that fat returns when removed. We undertook a 1-year randomized-controlled trial of suction lipectomy versus no int...
