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Synthesis of Morphine Alkaloids and Derivatives.

06:00 EDT 7th May 2011 | BioPortfolio

Summary of "Synthesis of Morphine Alkaloids and Derivatives."

: This review summarizes recent developments in the total synthesis of morphine alkaloids and some of the semisynthetic derivatives. The literature is covered for the period of 5 years after the publication of the last review in 2005. The syntheses that appeared in this period are covered in detail and are placed in the context of all syntheses of opiate alkaloids since the original one published by Gates in 1952. The introduction covers the historical aspects of total synthesis of these alkaloids. The synthesis of some of the medicinally useful derivatives is reviewed in the last section along with some of the methodology required for their preparation.

Affiliation

Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria, uwe.rinner@univie.ac.at.

Journal Details

This article was published in the following journal.

Name: Topics in current chemistry
ISSN: 0340-1022
Pages:

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Medical and Biotech [MESH] Definitions

Analogs or derivatives of morphine.

Morphine derivatives of the methanobenzazocine family that act as potent analgesics.

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

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