Characteristic Neurobiological Patterns Differentiate Paternal Responsiveness in Two Peromyscus Species.

13:32 EDT 30th March 2015 | BioPortfolio

Summary of "Characteristic Neurobiological Patterns Differentiate Paternal Responsiveness in Two Peromyscus Species."

Rodent paternal models provide unique opportunities to investigate the emergence of affiliative social behavior in mammals. Using biparental and uniparental Peromyscus species (californicus and maniculatus, respectively) we assessed paternal responsiveness by exposing males to biological offspring, unrelated conspecific pups, or familiar brothers following a 24-hour separation. The putative paternal circuit we investigated included brain areas involved in fear/anxiety [cingulate cortex (Cg), medial amygdala (MeA), paraventricular nucleus of the hypothalamus (PVN), and lateral septum (LS)], parental motivation [medial preoptic area (MPOA)], learning/behavioral plasticity (hippocampus), olfaction [pyriform cortex (PC)], and social rewards (nucleus accumbens). Paternal experience in californicus males reduced fos immunoreactivity (ir) in several fear/anxiety areas; additionally, all californicus groups exhibited decreased fos-ir in the PC. Enhanced arginine vasopressin (AVP) and oxytocin (OT)-ir cell bodies and fibers, as well as increased neuronal restructuring in the hippocampus, were also observed in californicus mice. Multidimensional scaling analyses revealed distinct brain activation profiles differentiating californicus biological fathers, pup-exposed virgins, and pup-naïve virgins. Specifically, associations among MPOA fos, CA1 fos, dentate gyrus GFAP, CA2 nestin-, and PVN OT-ir characterized biological fathers; LS fos-, Cg fos-, and AVP-ir characterized pup-exposed virgins, and PC-, PVN-, and MeA fos-ir characterized pup-naïve virgins. Thus, whereas fear/anxiety areas characterized pup-naïve males, neurobiological factors involved in more diverse functions such as learning, motivation, and nurturing responses characterized fatherhood in biparental californicus mice. Less distinct paternal-dependent activation patterns were observed in uniparental maniculatus mice. These data suggest that dual neurobiological circuits, leading to the inhibition of social-dependent anxiety as well as the activation of affiliative responses, characterize the transition from nonpaternal to paternal status in californicus mice.


Department of Psychology, Randolph-Macon College, Ashland, Va., USA.

Journal Details

This article was published in the following journal.

Name: Brain, behavior and evolution
ISSN: 1421-9743
Pages: 159-175


PubMed Articles [14368 Associated PubMed Articles listed on BioPortfolio]

Peromyscus (deer mice) as developmental models.

Deer mice (Peromyscus) are the most common native North American mammals, and exhibit great natural genetic variation. Wild-derived stocks from a number of populations are available from the Peromyscu...

Intra- and inter-individual variation masks inter-species variation in the microbiota of sympatric Peromyscus populations.

Using populations of two sympatric Peromyscus species we characterized the importance of host species, physiology, environment, diet, and other factors in shaping structure and dynamics of their gut m...

Paternal postpartum depression: A review.

Postpartum depression affects 1 in 10 fathers worldwide. Paternal PPD tends to develop gradually during the first year. Maternal depression is one of the most important risk factors for depression in ...

Autophagy and ubiquitin-mediated proteolysis may not be involved in the degradation of spermatozoon mitochondria in mouse and porcine early embryos.

Summary The mitochondrial genome is maternally inherited in animals, despite the fact that paternal mitochondria enter oocytes during fertilization. Autophagy and ubiquitin-mediated degradation are re...

Intraspecific Polymorphism, Interspecific Divergence, and the Origins of Function-Altering Mutations in Deer Mouse Hemoglobin.

Major challenges for illuminating the genetic basis of phenotypic evolution are to identify causative mutations, to quantify their functional effects, to trace their origins as new or pre-existing var...

Clinical Trials [936 Associated Clinical Trials listed on BioPortfolio]

Brain Electrophysiological Patterns in Obesity

There is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP) elic...

Influence of Paternal Age on Assisted Reproduction Outcome

In the recent years, there is an increasing tendency to the parenthood delay in developed countries, and there is not enough information available regarding the influence of the male's age...

Neurocognitive and Neurobiological Improvement in ADHD Children by Modification of Dietary Protein

Multicenter, Prospective, randomized, comparative and controlled study about the beneficial effects in behavior and brain connectivity of different dietary patterns in 100 children with AD...

Changing Patterns of Candida Infections in Urban Medical Centers

The purpose of this study is to determine the changing patterns of infection caused by Candida species in urban medical centers and its influence on patient outcomes. A retrospective coh...

Validation of RealAmp Method for the Diagnosis of Malaria in Endemic Areas of Brazil

Worldwide, approximately 2 billion people live in areas at risk for malaria with morbidity surpassing 250 million cases, with approximately 800,000 deaths, per year. Of the four species of...

Medical and Biotech [MESH] Definitions

The behavior patterns associated with or characteristic of a father.

Stereotyped patterns of response, characteristic of a given species, that have been phylogenetically adapted to a specific type of situation.

A genus of the subfamily SIGMODONTINAE consisting of 49 species. Two of these are widely used in medical research. They are P. leucopus, or the white-footed mouse, and P. maniculatus, or the deer mouse.

The behavior patterns associated with or characteristic of a mother.

A personality inventory consisting of statements to be asserted or denied by the individual. The patterns of response are characteristic of certain personality attributes.

Search BioPortfolio:

Relevant Topics

Alzheimer's Disease
Latest News Clinical Trials Research Drugs Reports Corporate
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Latest News Clinical Trials Research Drugs Reports Corporate
Psychiatry is the study of mental disorders and their diagnosis, management and prevention.  Conditions include schizophrenia, severe depression and panic disorders among others. There are pharmaceutical treatments as well as other therapies to help...


Searches Linking to this Article