Acinar cell carcinoma of the pancreas associated with subcutaneous panniculitis.
Summary of "Acinar cell carcinoma of the pancreas associated with subcutaneous panniculitis."
Acinar cell carcinoma is a rare pancreatic malignant tumor, which can be associated with a particular manifestation: pancreatic panniculitis. It presents with erythematous subcutaneous nodules located mainly on the legs. The skin lesions can precede, be concurrent with or follow the pancreatic illness. The pathogenesis is not fully understood, but it is believed to be associated with high levels of serum lipase produced by the neoplasm, causing fat necrosis in tissues. The treatment of pancreatic panniculitis is directed at the underlying pancreatic disease, which may result in regression of the skin lesions. We report a case of pancreatic acinar cell carcinoma associated with subcutaneous panniculitis together with a review of the English literature.
Affiliation
Fourth Surgical Clinic, Department of Surgery, University of Padua. Padua, Italy. csperti@libero.it.
Journal Details
This article was published in the following journal.
Name: JOP : Journal of the pancreas
ISSN: 1590-8577
Pages: 292-6
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21546712
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Pancreas, Exocrine
The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Panniculitis, Nodular Nonsuppurative
A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. The condition is most often seen in women, alone or in association with other disorders.
Panniculitis
General term for inflammation of adipose tissue, usually of the skin, characterized by reddened subcutaneous nodules.
Carcinoma, Non-small-cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
PubMed Articles
Histopathology of panniculitis - aspects of biopsy techniques and difficulties in diagnosis.
Background: Clinical and histologic diagnosis of panniculitis may be difficult. The patients usually present with erythematous subcutaneous nodules with or without additional symptoms. If a skin biops...
Demonstration of T-cell receptor gene monoclonality often plays an important role in the diagnosis of T-cell lymphoma. When a test to detect monoclonality is performed on whole tissue sections, the pr...
Intraductal growing acinar cell carcinoma of the pancreas.
Acinar cell carcinoma (ACC) is a rare pancreatic exocrine neoplasm characterized by a huge, exophytic well-circumscribed hypovascular mass. There has been several reports describing intraductal and pa...
Expression of claudin-5 in canine pancreatic acinar cell carcinoma - An immunohistochemical study.
Claudin-5 is an endothelium-specific tight junction protein. The aim of the present study was to detect the expression pattern of this molecule in intact pancreatic tissues and in well-differentiated...
The role of protein synthesis and digestive enzymes in acinar cell injury.
The exocrine pancreas is the organ with the highest level of protein synthesis in the adult-each day the pancreas produces litres of fluid filled with enzymes that are capable of breaking down nearly...
Clinical Trials
Cytokines in Patients With Metastatic Renal Cell Carcinoma of Intermediate Prognosis
The PERCY Quattro trial has been designed to evaluate the survival benefit of two cytokine treatments, Interleukin-2 (IL2) and/or alpha interferon (IFN), for patients with intermediate cha...
The purpose of this study is to determine, by means of DNA and protein analysis, the relationship between DNA and protein profiles and a number of endpoints which are important for the pat...
Adjuvant BEmiparin in Small Cell Lung Carcinoma (ABEL STUDY)
Main objective: To evaluate whether the subcutaneous administration (sc) of Bemiparin (3,500 UI/day) for 26 weeks, starting on the first day of chemotherapy (CT), delays tumoral spread an...
Role of Pancreatic Triglyceride Content in Beta-cell Function
The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the...
This is a investigator-initiated, single-center, prospective study to evaluate endoscopic ultrasound (EUS) as a diagnostic test for chronic pancreatitis (CP). EUS detects abnormalities of...
