Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum.

06:32 EST 20th December 2014 | BioPortfolio

Summary of "Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum."

The cardiovascular effects of the water extract from fresh leaves of P. palatiferum (PP) were evaluated in rats in both in vivo and in vitro models. The PP extract consisted of alkaloids, coumarins and sterols. The extract (5-25 mg/kg, I.V.) decreased both the mean arterial blood pressure and heart rate of normotensive and
L:
-N-(ω)-nitro-arginine methyl ester (
L:
-NAME)-induced hypertensive anesthetized rats. The extract caused relaxation of the norepinephrine-contracted endothelium-intact aorta ring (EC(50) = 81.0 μg/mL). Functional removal of the endothelium attenuated the vasodilatation effect of the extract (EC(50) = 136.4 μg/mL). Pretreatment with
L:
-NAME or atropine did not alter the vasodilation effect of the extract. Pre-incubation with atropine did not alter bradycardic effect of the extract on isolated rat atrium. The effects of isoproterenol on isolated atrium were attenuated by the extract (2.5-5 mg/mL). In conclusion, the water extract from fresh leaves of P. palatiferum possessed hypotensive and bradycardic effects. The vasorelaxant effect of the extract was dependent partly on the vascular endothelium but was not dependent on the synthesis of nitric oxide and did not act through activation of the muscarinic receptor.

Affiliation

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand, wparirat@hotmail.com.

Journal Details

This article was published in the following journal.

Name: Journal of natural medicines
ISSN: 1861-0293
Pages:

Links

PubMed Articles [16643 Associated PubMed Articles listed on BioPortfolio]

Intracellular ROS Scavenging Activity and Downregulation of Inflammatory Mediators in RAW264.7 Macrophage by Fresh Leaf Extracts of Pseuderanthemum palatiferum.

Beneficial antioxidant phytochemicals are found in many medicinal plants. Pseuderanthemum palatiferum (PP), a well-known Vietnamese traditional medicinal plant in Thailand, has long been used in folk ...

Diuretic Activity of the Aqueous Extract Leaves of Ficus glumosa Del. (Moraceae) in Rats.

Experiments were carried out to validate the use of F. glumosa extract as a diuretic in the treatment of hypertension as claimed by traditional healers. The experiments were performed under the same c...

Effect of leaf extracts of Taraxacum officinale on CCl4 induced Hepatotoxicity in rats, in vivo study.

Taraxacum officinale L is a medicinal plant, which has enormous medicinal values against various types of liver disorders and it has traditionally been used for the treatment of liver problems by peop...

An Assessment of Wound Healing Potential of Argyreia speciosa Leaves.

In North India, poultice of young unfolded leaves of Argyreia speciosa Linn. (Convolvulaceae) is used for healing wounds. In order to find scientific evidence for the traditional utilization of leaves...

Hypotensive Effects and Angiotensin-Converting Enzyme Inhibitory Peptides of Reishi (Ganoderma lingzhi) Auto-Digested Extract.

Reishi (Ganoderma lingzhi) has been used as a traditional medicine for millennia. However, relatively little is known about this mushroom's proteins and their bioactivities. In this study, we used rei...

Clinical Trials [1539 Associated Clinical Trials listed on BioPortfolio]

Antihypertensive Effect of Simvastatin in Hypertensive Patients

Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive eff...

Bioavailability and Vascular Effects of Apple Polyphenols

The main purpose of this study is to determine the oral bioavailability of flavanols (polyphenolic compounds) from apple granules and an apple extract delivered in a water based beverage ...

The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

Study of the Effects of a Mineralized Water Ingestion Upon Lipidic Absorption Mechanisms

The principal objective of this research is the evaluation of the effect of mineralized water consumption upon evolution of LDL Cholesterol and triglycerides, compared to a low mineralized...

Effects of Water-soluble Olive Extract Supplementation

Six weeks of supplementation of an olive extract will: - Improve antioxidant status - Reduce inflammation - Reduce muscle damage - Improve exercise performance ...

Medical and Biotech [MESH] Definitions

A dehydrated extract of thyroid glands. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.

Adverse effect upon bodies of water (lakes, RIVERS, seas, groundwater etc.) caused by CHEMICAL WATER POLLUTANTS.

The loss of water vapor by plants to the atmosphere. It occurs mainly from the leaves through pores (stomata) whose primary function is gas exchange. The water is replaced by a continuous column of water moving upwards from the roots within the xylem vessels. (Concise Dictionary of Biology, 1990)

An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed)

A plant genus of the family ASTERACEAE. The common name of thoroughwort is also used for other plants including EUPATORIUM; CHROMOLAENA, Hebeclinium and Koanophyllon. Eupolin is the aqueous extract of the leaves.

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Cardiology
Latest News Clinical Trials Research Drugs Reports Corporate
Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Cardiovascular disease (CVD)
Latest News Clinical Trials Research Drugs Reports Corporate
Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina and heart attack), heart failure, congenital heart disease and stroke. It is also known as heart and circulatory disease. Coron...

Blood
Latest News Clinical Trials Research Drugs Reports Corporate
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Advertisement