Changes in the mRNA Levels of α(2A) and α (2C) Adrenergic Receptors in Rat Models of Parkinson's Disease and L: -DOPA-Induced Dyskinesia.
Summary of "Changes in the mRNA Levels of α(2A) and α (2C) Adrenergic Receptors in Rat Models of Parkinson's Disease and L: -DOPA-Induced Dyskinesia."
The changes in the mRNA levels of α(2A) and α(2C) adrenoceptors were investigated in unilateral 6-OHDA-lesioned rat model of Parkinson's disease and
L:
-DOPA-induced dyskinesia using in situ hybridization. In the untreated 6-OHDA-lesioned rats, α(2A) expression was elevated in the locus coeruleus (160 ± 8% and 142 ± 8% in lesioned and unlesioned sides compared to the comparable side in sham-operated rats). Following long-term (21 days, twice daily) treatment with
L:
-DOPA (25 mg/kg
L:
-DOPA methyl ester plus benserazide 6.25 mg/kg) in 6-OHDA-lesioned rats, levels of α(2A) adrenoceptor mRNA in the locus coeruleus were decreased, compared to the 6-OHDA-lesioned rats, returning to the levels of α(2A) mRNA in the sham-operated rats. α(2A) adrenoceptor expression was not changed in other brain regions in any treatment group. There was no change in α(2C) expression in the rostral or caudal striatum in which the highest density of α(2C) mRNA is present. In conclusion, the data presented in this study demonstrate an increase in α(2A) adrenoceptor mRNA in the locus coeruleus in the 6-OHDA-lesioned rat model of Parkinson's disease. In addition, the data show that repeated treatment with
L:
-DOPA in 6-OHDA-lesioned rats, which induces dyskinesia, restores α(2A) mRNA levels. These changes of α(2A) mRNA expression, observed in the locus coeruleus, might be of importance to basal ganglia transmission and motor function.
Affiliation
Department of Pharmacology, Faculty of Pharmacy, University of Aleppo, P.O. Box. 8119, Aleppo, Syria, amalachkar1@yahoo.co.uk.
Journal Details
This article was published in the following journal.
Name: Journal of molecular neuroscience : MN
ISSN: 1559-1166
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21562737
- DOI: http://dx.doi.org/10.1007/s12031-011-9539-x
Medical and Biotech [MESH] Definitions
Receptors, Adrenergic, Beta-3
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.
Receptors, Adrenergic, Beta-1
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-1 Adrenergic receptors are equally sensitive to epinephrine and norepinephrine and bind the agonist dobutamine and the antagonist metoprolol with high affinity. They are found in the heart, juxtaglomerular cells, and in the central and peripheral nervous systems.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Receptors, Adrenergic, Alpha-2
A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-2 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist clonidine and the antagonist yohimbine. They are found on pancreatic beta cells, platelets, and VASCULAR SMOOTH MUSCLE, as well as both pre- and postsynaptically in the central and peripheral nervous systems.
Receptors, Adrenergic, Alpha-1
A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-1 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist phenylephrine and the antagonist prazosin. They are widespread, with clinically important concentrations in the liver, the heart, vascular, intestinal, and genitourinary smooth muscle, and the central and peripheral nervous systems.
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