Effect of Aqueous Cream BP on Human Stratum Corneum In Vivo.
Summary of "Effect of Aqueous Cream BP on Human Stratum Corneum In Vivo."
Summary Background - Aqueous Cream BP is widely prescribed to eczema patients to relieve skin dryness. The formulation contains sodium lauryl sulphate (SLS) - a chemical that is a known skin irritant and a commonly used excipient in personal care and household products. The chronic effects of Aqueous Cream BP application on skin barrier function have not been determined. Objectives - To characterise and assess skin barrier function of healthy skin after application of Aqueous Cream BP and to study the physical effects of the formulation on the stratum corneum (SC). Methods - The left and right volar forearms of six human volunteers were each separated into treated and control sides. The treated sides of each forearm were subjected to twice daily applications of Aqueous Cream BP for four weeks at the end of which concomitant tape-stripping and transepidermal water loss (TEWL) measurements were made. The untreated sides of the forearms were not exposed to any products containing SLS during the study period. Results - Changes in stratum corneum (SC) thickness, baseline TEWL and rate of increase in TEWL during tape stripping were observed in skin treated with Aqueous Cream BP. The mean decrease in stratum corneum (SC) thickness was 1.1mum (18%) (P = 0.0016) and the average increase in baseline TEWL was 2.5 g.m(-2).h(-1) (32%) (P < 0.0001). Reduced SC thickness and an increase in baseline TEWL, as well as a faster rate of increase in TEWL during tape stripping, were observed in 16 out of 27 treated skin sites. Conclusions - The application of Aqueous Cream BP, containing approximately 1% SLS, has been shown to reduce the SC thickness of healthy skin and increase its permeability to water loss. These observations call into question the continued use of this emollient on the already compromised barrier of eczematous skin.
Affiliation
University of Bath, Department of Pharmacy & Pharmacology Claverton Down, Bath, BA2 7AY, U.K.
Journal Details
This article was published in the following journal.
Name: The British journal of dermatology
ISSN: 1365-2133
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20649794
- DOI: http://dx.doi.org/10.1111/j.1365-2133.2010.09954.x
Medical and Biotech [MESH] Definitions
Epidermis
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Parakeratosis
Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)
Keratoderma, Palmoplantar
Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).
Ichthyosis
Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.
Keratin-10
A type I keratin that is found associated with the KERATIN-1 in terminally differentiated epidermal cells such as those that form the stratum corneum. Mutations in the genes that encode keratin-10 have been associated with HYPERKERATOSIS, EPIDERMOLYTIC.
PubMed Articles
The stratum corneum of epidermis is an essential barrier against the external environment and water loss. This study aimed to develop an organotypic culture model that targets the reconstruction of th...
Lipid microparticles loaded with the complex between hydroxypropyl-β-cyclodextrin (HP-β-CD) and the sunscreen agent, butyl methoxydibenzoylmethane (BMDBM) were evaluated for their effect on the UV f...
Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function.
The objectives of this study were to identify a plant extract that would improve stratum corneum functions and to elucidate the mechanism(s) involved. Based on the information that stratum corneum fun...
Patients with atopic dermatitis (AD) have an epidermal barrier dysfunction, which allows invasion of allergens to occur. Stratum corneum skin barrier is formed by corneocytes and extracellular lipids...
Optimization of microdermabrasion for controlled removal of stratum corneum.
Microdermabrasion has been shown to increase skin permeability for transdermal drug delivery by damaging or removing skin's outer layer, stratum corneum. However, relationships between microdermabrasi...
Clinical Trials
Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous.
The purpose of this study is to assay human aqueous for bimatoprost and the presence of any metabolites, especially prostaglandin analogs. Hypothesis:Bimatoprost is not metabolized to a pr...
Transcriptomic Study of ER 4017 Topical Application in Elderly Subject
The stratum corneum (SC) is the superficial layer of the epidermis situated at the interface between the body and its outside environment. Its strategic position confers it a crucial role...
Effect of Moisturising Creams on Skin Moisture in Atopic Dermatitis
The aim of this study is evaluate the effect of three moisturising creams on Stratum corneum (SC) hydratation and barrier function.
Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients
The purpose of this study is to obtain and assay human aqueous samples following pre-operative dosing with 0.1% Brimonidine Purite™ (pH 7.8) or with 0.15% Brimonidine Purite® (pH 7.2) f...
to compare the atrophogenic potentials of pimecrolimus 1% cream, hydrocortisonacetat 1% cream, betamethasonvalerat 0,1% cream and clobetasol-17-Propionat 0,05% cream
