Therapeutic Potential of Mucoadhesive Drug Delivery Systems - An Updated Patent Review.
Summary of "Therapeutic Potential of Mucoadhesive Drug Delivery Systems - An Updated Patent Review."
There has been a burgeoning interest among the research scientists to associate the drugs to polymeric particulate systems due to the propensity of these systems to interact with the mucosal surface. Transmucosal delivery of drugs through mucosal lining of nasal, rectal, vaginal, ocular and oral cavity entails advantages like prolongation of residence time at the absorption site, enhanced contact with underlying mucosa eventually leading to enhanced absorption of the active ingredient. Such systems not only provide local targeting of drugs but also offer a better control over their systemic delivery. Hence the objective of the present review is to provide an overview of the mucoadhesive drug delivery systems with special emphasis on the intellectual aspects of these systems. This paper also attempts to extend the information present on mucoadhesive drug delivery systems in the existing literature by focussing on the update on the patents granted as well as applications published for these systems. Some newer mucoadhesive formulations like mucoadhesive microparticles and nanoparticles have also been discussed.
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura - 281001, Uttar Pradesh, India. firstname.lastname@example.org.
This article was published in the following journal.
Name: Recent patents on drug delivery & formulation
Medical and Biotech [MESH] Definitions
Drug Delivery Systems
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Synthesized magnetic particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds.
Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.
Adverse Drug Reaction Reporting Systems
Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
Introduction: Biopolymers have been used extensively in the pharmaceutical field. Pectin, a biopolymer, has several unique properties that enable it to be used as an excipient or carrier for oral drug...
Abstract Context: Mucoadhesive buccal films containing three layers (mucoadhesive layer, nanosuspension containing layer and backing membrane) were incorporated with carvedilol nanosuspension. Objecti...
The aim of this study was to formulate salbutamol sulfate (SS), a model drug, as mucoadhesive in situ gelling inserts having a high potential as nasal drug delivery system bypassing the first-pass met...
In the present era, gastroretentive dosage forms (GRDF) receive great attention because they can improve the performance of controlled release systems. An optimum GRDF system can be defined as a syste...
Particulate systems that could deliver drug specifically to duodenum have not yet been reported. The aim of this study was to develop a novel duodenum-specific drug delivery system based on thiolated...
The purpose of this study is to evaluate the safety and tolerability of a single iontophoretic dose of buffered solution administered through the EyeGate® II Drug Delivery System in healt...
Objectives: The objective of this study is to determine if any differences exist between the varying modes of portable oxygen delivery systems including liquid oxygen, a portable concentr...
The primary objective is to evaluate if patent foramen ovale (PFO) closure and antiplatelet medical management can reduce the risk of recurrent stroke or transient ischemic attack (TIA) wh...
Closure of Patent Foramen Ovale with the AMPLATZER® PFO OCCLUDER in patients with at least two cryptogenic strokes due to presumed paradoxical embolism through a patent foramen ovale and...
Adverse drug events (ADE) present a unique focus for error reduction. Computerized provider order entry, with embedded clinical decision support, has great promise in reducing medication e...