Therapeutic Potential of Mucoadhesive Drug Delivery Systems - An Updated Patent Review.
Summary of "Therapeutic Potential of Mucoadhesive Drug Delivery Systems - An Updated Patent Review."
There has been a burgeoning interest among the research scientists to associate the drugs to polymeric particulate systems due to the propensity of these systems to interact with the mucosal surface. Transmucosal delivery of drugs through mucosal lining of nasal, rectal, vaginal, ocular and oral cavity entails advantages like prolongation of residence time at the absorption site, enhanced contact with underlying mucosa eventually leading to enhanced absorption of the active ingredient. Such systems not only provide local targeting of drugs but also offer a better control over their systemic delivery. Hence the objective of the present review is to provide an overview of the mucoadhesive drug delivery systems with special emphasis on the intellectual aspects of these systems. This paper also attempts to extend the information present on mucoadhesive drug delivery systems in the existing literature by focussing on the update on the patents granted as well as applications published for these systems. Some newer mucoadhesive formulations like mucoadhesive microparticles and nanoparticles have also been discussed.
Affiliation
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura - 281001, Uttar Pradesh, India. vksbali@gmail.com.
Journal Details
This article was published in the following journal.
Name: Recent patents on drug delivery & formulation
ISSN: 1872-2113
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20649509
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Drug Delivery Systems
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Magnetite Nanoparticles
Synthesized magnetic particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds.
Nanodiamonds
Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.
Adverse Drug Reaction Reporting Systems
Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
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