Novel Mechanism of Cathepsinâ€…B Inhibition by Antibiotic Nitroxoline and Related Compounds.
Summary of "Novel Mechanism of Cathepsinâ€…B Inhibition by Antibiotic Nitroxoline and Related Compounds."
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Faculty of Pharmacy, University of Ljubljana, AĹˇkerÄŤeva 7, 1000 Ljubljana (Slovenia), Fax: (+386)â€‰1-42-58-031.
This article was published in the following journal.
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21598397
- DOI: http://dx.doi.org/10.1002/cmdc.201100098
Medical and Biotech [MESH] Definitions
Protein Synthesis Inhibitors
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
A cysteine endopeptidase found in NATURAL KILLER CELLS and CYTOTOXIC T-LYMPHOCYTES. It may have a specific function in the mechanism or regulation of cytolytic activity of immune cells.
An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the cells of the immune system where it may play a role in processing of CELL SURFACE ANTIGENS.
A lysosomal papain-related cysteine proteinase that is expressed in a broad variety of cell types.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
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Purpose The emergence and rapid rise in antibiotic resistance among common bacteria are adversely affecting the clinical course and health care costs of community-acquired infections. Beca...