Thalassemia: therapeutic hopes carried by hepcidin.
Summary of "Thalassemia: therapeutic hopes carried by hepcidin."
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Affiliation
Inserm U1016, CNRS UMR 8104, Institut Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Journal Details
This article was published in the following journal.
Name: Medecine sciences : M/S
ISSN: 0767-0974
Pages: 473-475
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21609665
- DOI: http://dx.doi.org/10.1051/medsci/2011275009
Medical and Biotech [MESH] Definitions
Beta-thalassemia
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Delta-thalassemia
A hereditary disorder characterized by reduced or absent DELTA-GLOBIN thus effecting the level of HEMOGLOBIN A2, a minor component of adult hemoglobin monitored in the diagnosis of BETA-THALASSEMIA.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Alpha-thalassemia
A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.
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Thalassemias are inherited blood disorders that can cause anemia and other health problems. The goal of this study is to collect information on complications of the disease among people wh...
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