Xeroderma pigmentosum: a useful model to study the relation between genomic mutations and cell transformation.
Summary of "Xeroderma pigmentosum: a useful model to study the relation between genomic mutations and cell transformation."
No Summary Available
Affiliation
Inserm U1035, Bordeaux, F-33000, France; Université Bordeaux Segalen, Bordeaux, F-33000, France.
Journal Details
This article was published in the following journal.
Name: Medecine sciences : M/S
ISSN: 0767-0974
Pages: 467-470
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21609663
- DOI: http://dx.doi.org/10.1051/medsci/2011275007
Medical and Biotech [MESH] Definitions
Xeroderma Pigmentosum Group D Protein
A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM.
Xeroderma Pigmentosum Group A Protein
A ZINC FINGER MOTIF protein that recognizes and interacts with damaged DNA. It is a DNA-binding protein that plays an essential role in NUCLEOTIDE EXCISION REPAIR. Mutations in this protein are associated with the most severe form of XERODERMA PIGMENTOSUM.
Xeroderma Pigmentosum
A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
Transcription Factor Tfiih
A general transcription factor that is involved in basal GENETIC TRANSCRIPTION and NUCLEOTIDE EXCISION REPAIR. It consists of nine subunits including ATP-DEPENDENT DNA HELICASES; CYCLIN H; and XERODERMA PIGMENTOSUM GROUP D PROTEIN.
Models, Statistical
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
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