Pd-catalyzed intermolecular C-h amination with alkylamines.
Summary of "Pd-catalyzed intermolecular C-h amination with alkylamines."
C-H amination of N-aryl benzamides with O-benzoyl hydroxylamines has been achieved with either Pd(II) or Pd(0) catalysts. Furthermore, we demonstrate that secondary amines can be directly used with benzoyl peroxide in a one-pot procedure that proceeds via the in situ generation of the appropriate O-benzoyl hydroxylamines. This catalytic reaction provides a new disconnection for the convergent synthesis of tertiary and secondary arylalkyl amines starting from benzoic acids.
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
This article was published in the following journal.
Name: Journal of the American Chemical Society
Medical and Biotech [MESH] Definitions
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