Decreased Serum Betaine Concentrations in Patients after Bariatric Surgery.
Summary of "Decreased Serum Betaine Concentrations in Patients after Bariatric Surgery."
Bariatric surgery significantly reduces the risk of cardiovascular diseases but has no effects on hyperhomocysteinemia, the risk factor for atherogenesis. We hypothesize that the decrease in serum betaine (involved in homocysteine metabolism) concentrations, after bariatric surgery, impairs conversion of homocysteine to methionine, leading to hyperhomocysteinemia. If this is true, it may be desirable to supply patients after bariatric surgery with betaine. Serum betaine and homocysteine concentrations were measured by liquid chromatography/mass spectrometry, in 16 obese patients, before and 6 months after bariatric surgery. Ten healthy individuals with normal body mass index served as controls. Serum betaine concentrations decreased to the values lower than in controls after bariatric surgery, whereas serum homocysteine concentrations remained elevated. In patients supplemented with B(12) and folate, no effect of bariatric surgery on serum concentrations of vitamins involved in homocysteine metabolism was observed. These results suggest that betaine deficit could be responsible for maintenance of hyperhomocysteinemia after bariatric surgery. We postulate that supplementation with betaine could be of therapeutic value for the treatment of hyperhomocysteinemia after bariatric surgery.
Affiliation
Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1, 80-241, Gdansk, Poland.
Journal Details
This article was published in the following journal.
Name: Obesity surgery
ISSN: 1708-0428
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21618064
- DOI: http://dx.doi.org/10.1007/s11695-011-0451-9
Medical and Biotech [MESH] Definitions
Bariatric Surgery
Surgical procedures aimed at producing major WEIGHT REDUCTION in patients with MORBID OBESITY.
Bariatrics
Activities related to WEIGHT REDUCTION in patients with OBESITY. Treatment methods include DIET; EXERCISE; BEHAVIOR MODIFICATION; medications; and BARIATRIC SURGERY.
Serum Amyloid A Protein
An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.
Betaine
A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
Bariatric Medicine
The discipline concerned with WEIGHT REDUCTION in patients with OBESITY.
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