Association between genes encoding components of the IL-10/IL-0 receptor pathway and asthma in children.
Summary of "Association between genes encoding components of the IL-10/IL-0 receptor pathway and asthma in children."
Asthma is a chronic inflammation of the airways associated with recurrent symptoms that range from mild to debilitating. Interleukin-10 (IL-10) is a cytokine that displays pleiotropic effects in asthma and allergy.
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
This article was published in the following journal.
Name: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21624746
- DOI: http://dx.doi.org/10.1016/j.anai.2011.02.021
Medical and Biotech [MESH] Definitions
Genes, T-cell Receptor Alpha
DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.
Genes, T-cell Receptor Beta
DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.
A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.
Antley-bixler Syndrome Phenotype
An inherited condition characterized by multiple malformations of CARTILAGE and bone including CRANIOSYNOSTOSIS; midface hypoplasia; radiohumeral SYNOSTOSIS; CHOANAL ATRESIA; femoral bowing; neonatal fractures; and multiple joint CONTRACTURES and, occasionally, urogenital, gastrointestinal or cardiac defects. In utero exposure to FLUCONAZOLE, as well as mutations in at least two separate genes are associated with this condition - POR (encoding P450 (cytochrome) oxidoreductase (NADPH-FERRIHEMOPROTEIN REDUCTASE)) and FGFR2 (encoding FIBROBLAST GROWTH FACTOR RECEPTOR 2).
Exons that are created in vivo during LYMPHOCYTE maturation from the V, D, and J gene segments of immunoglobulin superfamily genes (e.g., the IMMUNOGLOBULIN HEAVY CHAIN GENES, or the T-CELL RECEPTOR BETA GENES or T-CELL RECEPTOR GAMMA GENES ) by the VDJ RECOMBINASE system.
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To conduct molecular genetic studies in human pedigrees in order to identify the major genes responsible for asthma.
To identify susceptibility genes associated with asthma and asthma related phenotypes.