Effects of dietary aflatoxin on the health and performance of growing barrows.
Summary of "Effects of dietary aflatoxin on the health and performance of growing barrows."
Aflatoxins, especially aflatoxin B1 (AFB1), can be high in dried distillers grains with solubles (DDGS) because it can be concentrated during the ethanol production process. Increased use of DDGS in swine diets could potentially lead to an increased incidence of aflatoxicosis, a disease associated with decreased feed intake, reduced BW gain, and impaired liver function. The objective of this study was to determine the effects of AFB1 on the health, performance, and serum profile of growing barrows. Ninety Duroc x Yorkshire crossbred barrows were purchased (age = 35 +/- 5 d; BW = 14.2 +/- 3.0 kg), allocated to 9 pens with 10 pigs per pen, and randomly assigned to receive diets containing 0 ppb AFB1 (CON), 250 ppb AFB1 (LOW), or 500 ppb AFB1 (HIGH) for 7, 28, or 70 d in a 3 x 3 factorial arrangement of treatments. Feed intake was measured daily, and pigs were weighed and blood samples collected weekly. Serum was analyzed for concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (BILI), and blood urea nitrogen (BUN). Both ADFI and ADG were negatively affected (P
Affiliation
Department of Animal Science, University of Wyoming, Laramie, WY 82071.
Journal Details
This article was published in the following journal.
Name: Journal of animal science
ISSN: 1525-3163
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20656968
- DOI: http://dx.doi.org/10.2527/jas.2009-2663
Medical and Biotech [MESH] Definitions
Aflatoxins
Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
Aflatoxin B1
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Rotarod Performance Test
A performance test based on forced MOTOR ACTIVITY on a rotating rod, usually by a rodent. Parameters include the riding time (seconds) or endurance. Test is used to evaluate balance and coordination of the subjects, particular in experimental animal models for neurological disorders and drug effects.
Aflatoxin M1
A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Radiologic Health
Health concerns associated with the effects of radiation on the environment and on public and personal health.
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