Benefits and drawbacks of zinc in glass ionomer bone cements.

16:47 EDT 31st March 2015 | BioPortfolio

Summary of "Benefits and drawbacks of zinc in glass ionomer bone cements."

Glass polyalkenoate (ionomer) cements (GPCs) based on poly(acrylic acid) and fluoro-alumino-silicate glasses are successfully used in a variety of orthopaedic and dental applications; however, they release small amounts of aluminium, which is a neurotoxin and inhibits bone mineralization in vivo. Therefore there has been significant interest in developing aluminium-free glasses containing zinc for forming GPCs because zinc can play a similar structural role in the glass, allowing for glass degradation and subsequent cement setting, and is reported to have beneficial effects on bone formation. We created zinc-containing GPCs and characterized their mechanical properties and biocompatibility. Zinc-containing cements showed adhesion to bone close to 1 MPa, which was significantly greater than that of zinc-free cements (<0.05 MPa) and other currently approved biological adhesives. However, zinc-containing cements produced significantly lower metabolic activity in mouse osteoblasts exposed to cell culture medium conditioned with the cements than controls. Results show that although low levels of zinc may be beneficial to cells, zinc concentrations of 400 µM Zn(2+) or more resulted in cell death. In summary, we demonstrate that while zinc-containing GPCs possess excellent mechanical properties, they fail basic biocompatibility tests, produce an acute cytotoxic response in vitro, which may preclude their use in vivo.


Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK.

Journal Details

This article was published in the following journal.

Name: Biomedical materials (Bristol, England)
ISSN: 1748-605X
Pages: 045007


PubMed Articles [7787 Associated PubMed Articles listed on BioPortfolio]

Push-out bond strength of fiber posts to root dentin using glass ionomer and resin modified glass ionomer cements.

The purpose of this study was to assess the push-out bond strength of glass fiber posts to root dentin after cementation with glass ionomer (GICs) and resinmodified glass ionomer cements (RMGICs).

Dental materials for primary dentition: are they suitable for occlusal restorations? A two-body wear study.

This was to evaluate the wear resistance of different materials, compomers, resin-modified glass ionomer cements (RMGICs), glass ionomer cements (GICs), used for posterior restorations in primary teet...

Effect of immersion time of restorative glass ionomer cements and immersion duration in calcium chloride solution on surface hardness.

The objective of this study was to evaluate the effect of immersion time of restorative glass ionomer cements (GICs) and immersion duration in calcium chloride (CaCl2) solution on the surface hardness...

Comparison of Micro-Leakage from Resin-Modified Glass Ionomer Restorations in Cavities Prepared by Er:YAG (Erbium-Doped Yttrium Aluminum Garnet) Laser and Conventional Method in Primary Teeth.

In recent years, significant developments have been taking place in caries removal and cavity preparation using laser in dentistry. As laser use is considered for cavity preparation, it is necessary t...

Evaluation of Novel Injectable Strontium-containing Borate Bioactive Glass Cement with Enhanced Osteogenic Capacity in a Critical-sized Rabbit Femoral Condyle Defect Model.

The development of a new generation of injectable bone cements that are bioactive and have enhanced osteogenic capacity for rapid osseointegration is receiving considerable interest. In this study, a ...

Clinical Trials [2269 Associated Clinical Trials listed on BioPortfolio]

Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries

The goal of this project is to conduct a community-based randomized clinical trial to compare the caries prevention efficacy of fluoride varnish applied every six months vs. fluoride varni...

Outcome Evaluation of Ceramic Crowns Using Two Different Dental Cements

The restoration of indirect partial and full coverage restorations in dentistry necessitates the use of a luting agent to act as a means of mechanical and potentially, chemical retention o...

A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement

The purpose of this study is to monitor the performance of artificial hip joints implanted with two different bone cements, SmartSet® HV and SmartSet® GHV, in the treatment of patients w...

Comparison of Bioactive Glass and Beeta-Tricalcium Phosphate as Bone Graft Substitute

This study is designed to perform a head-to-head comparison of two synthetic ceramic bone graft substitutes, bioactive glass (BAG) and beeta-tricalcium phosphate (TCP), in filling of conta...

A Randomised Single Centre Study to Compare the Long-term Performance of SmartSet® HV and Palacos® R Bone Cements in Primary Total Hip Replacement

The purpose of this study is to monitor the stability of a total hip replacement within the thigh bone when used in artificial hip joints implanted with two different bone cements, SmartSe...

Medical and Biotech [MESH] Definitions

Fluoride-releasing restorative materials made by the sintering of metal (usually silver) particles to glass ionomer powder. Glass ionomers are fluoride-releasing cements that are not very durable. Sintering of the metal particles is a means of improving those physical properties that will make the glass ionomer cement more durable.

Composite materials composed of an ion-leachable glass embedded in a polymeric matrix. They differ from GLASS IONOMER CEMENTS in that partially silanized glass particles are used to provide a direct bond to the resin matrix and the matrix is primarily formed by a light-activated, radical polymerization reaction.

A polymer obtained by reacting polyacrylic acid with a special anion-leachable glass (alumino-silicate). The resulting cement is more durable and tougher than others in that the materials comprising the polymer backbone do not leach out.

Treatment modality for DENTAL CARIES that uses manual excavation method and GLASS IONOMER CEMENTS. Because of its noninvasiveness and no need for expensive equipment and anesthesia it is promoted as an approach in places where dental care is not readily available.

Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.

Search BioPortfolio:

Relevant Topic

Latest News Clinical Trials Research Drugs Reports Corporate
Dentistry is the study, management and treatment of diseases and conditions affecting the mouth, jaw, teeth and their supporting tissues (Oxford Medical Dictionary) The work of a dentist ranges from regular patient check-up to orthodontics and surgery....