The Clinical Signifcance of Claudin-7 and Slug Expression in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Summary of "The Clinical Signifcance of Claudin-7 and Slug Expression in Lung Squamous Cell Carcinoma and Adenocarcinoma."
BACKGROUND:
The aim of this study is to investigate the expression of Claudin-7, Slug and their correltion with clinicopathological characteristics in lung squamous cell carcinoma and adenocarcinoma. We also investigated the relationship between the two factors.
METHODS:
The expressions of Claudin-7 and Slug in proteins were detected in 101 cases of lung squamous cell carcinoma and adenocarcinoma samples by immunohistochemistry SP method, and Western blot was applied to detect the expressions of Claudin-7 and Slug in 30 specimens of fresh lung cancer and corresponding paracancerous tissues.
RESULTS:
The expression of Claudin-7 was remarkably decreased in squamous cell carcinoma and adenocarcinoma tissues compared with normal lung tissue, and its expression level was closely correlated with differentiation grade and lymphatic metastasis (P<0.05), whereas the expression of Slug was significantly higher in cancer tissues than that in normal lung tissue. Outside differentiation grade and lymphatic metastasis, the expression of Slug was related to TNM stage (P<0.05). The expression of Claudin-7 was negatively correlated with the expression of Slug in lung squamous cell carcinoma and adenocarcinoma (r=-0.566,8).
CONCLUSIONS:
The down-regulation of Claudin-7 and overexpression of Slug might be one of pertinent biological markers for malignant transformation and metastasis of lung squamous cell carcinoma and adenocarcinoma.
Affiliation
Department of Pathology, China Medical University, Shenyang 110001, China.
Journal Details
This article was published in the following journal.
Name: Zhongguo fei ai za zhi = Chinese journal of lung cancer
ISSN: 1999-6187
Pages: 492-496
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21645451
- DOI: http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.03
Medical and Biotech [MESH] Definitions
Carcinoma, Non-small-cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Carcinoma, Bronchogenic
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Neoplasms, Squamous Cell
Neoplasms composed of squamous cells of the epithelium. The concept does not refer to neoplasms located in tissue composed of squamous elements.
Granular Cell Tumor
Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.
Carcinoma, Squamous Cell
A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
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