The use of atomic spectroscopy in the pharmaceutical industry for the determination of trace elements in pharmaceuticals.

22:04 EDT 29th July 2015 | BioPortfolio

Summary of "The use of atomic spectroscopy in the pharmaceutical industry for the determination of trace elements in pharmaceuticals."

The subject of the analysis of various elements, including metals and metalloids, in the pharmaceutical industry has seen increasing importance in the last 10-15 years, as modern analytical instrumentation has afforded analysts with the opportunity to provide element-specific, accurate and meaningful information related to pharmaceutical products. Armed with toxicological data, compendial and regulatory agencies have revisited traditional approaches to the testing of pharmaceuticals for metals and metalloids, and analysts have begun to employ the techniques of atomic spectroscopy, such as flame- and graphite furnace atomic absorption spectroscopy (FAAS, Flame AA or FAA and GFAAS), inductively coupled plasma-atomic emission spectroscopy (ICP-AES) and inductively coupled plasma-mass spectrometry (ICP-MS), to meet their analytical needs. Newer techniques, such as laser-induced breakdown spectroscopy (LIBS) and Laser Ablation ICP-MS (LAICP-MS) are also beginning to see wider applications in the analysis of elements in the pharmaceutical industry.This article will provide a perspective regarding the various applications of atomic spectroscopy in the analysis of metals and metalloids in drug products, active pharmaceutical ingredients (API's), raw materials and intermediates. The application of atomic spectroscopy in the analysis of metals and metalloids in clinical samples, nutraceutical, metabolism and pharmacokinetic samples will not be addressed in this work.

Affiliation

Bristol-Myers Squibb Co., Research and Development, Analytical R&D, 1 Squibb Drive, New Brunswick, NJ 08903, USA. Nancy.Lewen@bms.com

Journal Details

This article was published in the following journal.

Name: Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Pages: 653-61

Links

PubMed Articles [10160 Associated PubMed Articles listed on BioPortfolio]

Trace elements in the Fontinalis antipyretica from rivers receiving sewage of lignite and glass sand mining industry.

Intensive lignite and glass sand mining and industrial processing release waste which may contain elements hazardous to the aquatic ecosystem and constitute a potential risk to human health. Therefore...

Trace Elements and Radionuclides in Palm Oil, Soil, Water and Leaves from Oil Palm Plantations: A Review.

Oil palm (Elaeisguineensis) is one of the most productive oil producing plant in the world. Crude palm oil is composed of triglycerides supplying the world's need of edible oils and fats.Palm oil also...

Trace Elements in the Wall of Abdominal Aortic Aneurysms With and Without Coexisting Iliac Artery Aneurysms.

Iliac artery aneurysms (IAA) and abdominal aortic aneurysms (AAA) frequently coexist. It remains unknown whether the content of trace elements in AAA walls depends on the coexistence of IAAs. The aim ...

Improving Biomethane Production and Mass Bioconversion of Corn Stover Anaerobic Digestion by Adding NaOH Pretreatment and Trace Elements.

This research applied sodium hydroxide (NaOH) pretreatment and trace elements to improve biomethane production when using corn stover for anaerobic digestion. Full-factor experimental tests identified...

Rapid screening of heavy metals and trace elements in environmental samples using portable X-ray fluorescence spectrometer, A comparative study.

With industrialization, great amounts of trace elements and heavy metals have been excavated and released on the surface of the earth and dissipated into the environments. Rapid screening technology f...

Clinical Trials [659 Associated Clinical Trials listed on BioPortfolio]

Examining the Link Between Trace Elements and Cardiovascular Disease Risk Factors in Young Adults

Cardiovascular disease (CVD) affects millions of people in the United States; each year, more people die from CVD than from any other disease. There are many dietary and lifestyle factors ...

Evaluation of Toxic Metals, Trace Elements and Total Antioxidant Activity in Children With Recurrent Wheezing

The purpose of this study is to evaluate hair trace elements and toxic metals and plasma total antioxidant activity in children with recurrent wheezing and to evaluate whether these toxic ...

Intradialytic Parenteral Nutrition in Hemodialysis Patients

Malnutrition is a major cause of death in chronic hemodialysis patients. Primary treatment of malnutrition in these patients is dietetic counseling, additional enteral nutrition and occasi...

Content, Bioavailability and Health Effects of Trace Elements and Bioactive Components in Organic Agricultural Systems

Trace elements, bioactive secondary metabolites and vitamins are among the most important quality parameters in plants. Yet, very little information is available on their content, bioavail...

Long Term Clinical Evaluation of SLS Transtibial Sockets

The overall long-term goal of this project is the development of a clinically practical system for rapid prosthetic limb provision that integrates computer-aided design with solid freeform...

Medical and Biotech [MESH] Definitions

A trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.

A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.

Spectrophotometric techniques in which the samples are examined in the form of atoms based on their unique energy levels for ELECTRONS. They are used to analyze TRACE ELEMENTS, such as ALUMINUM; ARSENIC; BERYLLIUM; CALCIUM; COPPER; IRON; LEAD; and LITHIUM.

A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.


Advertisement
 

Relevant Topics

Blood
Latest News Clinical Trials Research Drugs Reports Corporate
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Drug Discovery
Latest News Clinical Trials Research Drugs Reports Corporate
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

The Top 100 Pharmaceutical Companies
Latest News Clinical Trials Research Drugs Reports Corporate
Top 10 biotech and pharmaceutical companies worldwide based on market value in 2014 Top 10 biotech and pharmaceutical companies worldwide based on market value in 2014 (in billion U.S. dollars) data Johnson & Johnson, U.S. 2...

Advertisement