C-reactive protein and heart rate recovery in middle-aged men with severe obstructive sleep apnea.
Summary of "C-reactive protein and heart rate recovery in middle-aged men with severe obstructive sleep apnea."
OBJECTIVE:
The study aimed to evaluate whether the inflammatory marker "high-sensitivity C-reactive protein (hsCRP)" level was associated with impaired heart rate recovery at 1 min after exercise termination (HRR-1) in middle-aged patients with severe obstructive sleep apnea (OSA).
METHODS:
Thirty middle-aged male patients (40-64 years old) with severe OSA (apnea-hypopnea index [AHI] ≥ 30 h(-1)) and 30 subjects without OSA (AHI < 5 h(-1)), matched with age and body mass index (BMI), were recruited. All subjects underwent an overnight polysomnography and completed a symptom-limited maximal exercise test. Cardiopulmonary parameters included peak oxygen consumption (VO(2peak)) and heart rate response during and immediately after exercise. Fasting blood samples were drawn for hsCRP analysis.
RESULT:
Patients with severe OSA had significantly higher hsCRP levels (0.18 vs. 0.07 mg/dl, P < 0.01), lower reduced HRR-1, peak heart rate, and VO(2peak) values than those in the controls. The hsCRP levels significantly correlated with HRR-1 in the OSA group (r = -0.69, P < 0.01) after adjustment for VO(2peak) (r = -0.66, P < 0.01). Furthermore, stepwise multiple regression analysis showed that HRR-1 and AHI were significant predictors of hsCRP levels in all participants (adjusted R (2) = 0.53, P < 0.01).
CONCLUSIONS:
Blunted HRR was shown in middle-aged men with severe OSA, and it was associated with high hsCRP levels significantly.
Affiliation
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng, Taipei, 10051, Taiwan.
Journal Details
This article was published in the following journal.
Name: Sleep & breathing = Schlaf & Atmung
ISSN: 1522-1709
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21706288
- DOI: http://dx.doi.org/10.1007/s11325-011-0549-2
Medical and Biotech [MESH] Definitions
Heart Rate, Fetal
The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
Heart, Artificial
A pumping mechanism that duplicates the output, rate, and blood pressure of the natural heart. It may replace the function of the entire heart or a portion of it, and may be an intracorporeal, extracorporeal, or paracorporeal heart. (Dorland, 28th ed)
Amnesia, Transient Global
A syndrome characterized by a transient loss of the ability to form new memories. It primarily occurs in middle aged or elderly individuals, and episodes may last from minutes to hours. During the period of amnesia, immediate and recent memory abilities are impaired, but the level of consciousness and ability to perform other intellectual tasks are preserved. The condition is related to bilateral dysfunction of the medial portions of each TEMPORAL LOBE. Complete recovery normally occurs, and recurrences are unusual. (From Adams et al., Principles of Neurology, 6th ed, pp429-30)
Maximal Midexpiratory Flow Rate
Measurement of rate of airflow over the middle half of a FORCED VITAL CAPACITY determination (from the 25 percent level to the 75 percent level). Common abbreviations are MMFR and FEF 25%-75%.
PubMed Articles
Assessment of heart rate recovery index in patients with familial Mediterranean fever.
Heart rate recovery after exercise is a function of vagal reactivation, and its impairment is an independent prognostic indicator for cardiovascular and all-cause mortality. The aim of our study was t...
OBJECTIVE: To examine prospectively the association of high-sensitivity C-reactive protein, interleukin 6, and fibrinogen with sudden death in asymptomatic European men. METHODS AND RESULTS: Among the...
Mild hypercapnia with hyperventilation attenuates recovery from anesthesia in elderly patients.
PURPOSE: Mild hypercapnia with hyperventilation has been reported to significantly decrease recovery time from inhaled anesthesia in young and middle-aged patients. However, its efficacy has not yet b...
OBJECTIVE: To compare the clinicopathological characteristics between elderly and young patients with colorectal cancer (CRC). METHODS: A total of 727 patients with CRC treated between Jan 2003 and De...
Arousals are often considered to be events which have an abrupt onset and offset, indicating abrupt changes in the state of the cortex. We hypothesized that cortical state, as reflected in electroence...
Clinical Trials
C-Reactive Protein as a Predictor of Stem Cell Transplant Complications
The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.
Protein S and Myocardial Infarction
To test the hypothesis that low levels of free protein S, a natural anticoagulant protein in plasma, were associated with an increased incidence of myocardial infarction in middle aged men...
Heart Rate Recovery and Mortality
To investigate whether impaired heart-rate recovery after exercise is a powerful and independent predictor of mortality.
Impact of a Sleep Debt in Middle-Aged and Older Adults
This project has 6 aims. 1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours. 2. To...
Balance Recovery and Training on Fall Prevention in Stroke
The specific aims of this research are delineated as the following: Aim 1: To investigate the neuromuscular and biomechanical mechanisms of the emerging processes of proactive and reactive...
