Track topics on Twitter Track topics that are important to you
Progress in medicine over recent decades has notably increased life expectancy in the Western world. Such advance implies that the treatment of degenerative processes associated with ageing has become one of the major tasks of current medicine and therapeutics. High expectation relies on stem cell research in order to apply cell therapies to ameliorate degenerative processes, remarkably those concerning the circulatory, locomotor and nervous systems. However, the skeletal connective tissues have revealed that cell plasticity is a factor of major importance in regenerative therapies. Most evidence indicates that connective tissue cells of cartilage, tendons, ligaments and fascia share common progenitors during their differentiation, which are regulated by a number of director genes and a panel of miRNAs coupled with transforming growth factor-β signalling. Furthermore, we know that not only stem cells but also differentiated cells from these tissues may dedifferentiate and redifferentiate, even one into another. Hence, modulation of cell plasticity might be a potential target for regenerative therapies in the future. In this review, we highlight classical concepts about the properties and differentiation of the connective tissues and their relation with recent advances in the study of stem cells, significant for regenerative medicine, paying special attention to cartilage and tendons. Copyright © 2011 John Wiley & Sons, Ltd.
Departamento de Anatomía y Biología Celular, Universidad de Cantabria/IFIMAV, Santander 39011, Spain.
This article was published in the following journal.
Name: Journal of tissue engineering and regenerative medicine
Regenerative medicine, which replaces or regenerates human cells, tissues or organs, to restore or establish normal function, is one of the fastest-evolving interdisciplinary fields in healthcare. Ove...
Mesenchymal stem cells (MSCs), which can be obtained from various organs and easily propagated in vitro, are one of the most extensively used types of stem cells and have been shown to be efficacious ...
Cartilage tissue engineering started to act as an alternative promising, even essential method in the process of cartilage repair and regeneration, considering the avascular structure with very limite...
Articular cartilage has been the focus of multiple strategies to improve its regenerative/ repair capacity. The Murphy Roths Large (MRL/MpJ) "super-healer" mouse demonstrates an unusual enhanced regen...
Curcumin, a compound extracted from the roots of Zingiberaceae has been proposed as a treatment for tissue injury but studies are yet to be done on its effect on tendon healing. Therefore, we performe...
The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage graft obtained by culturing expanded autologous nasal chondrocytes within a col...
The Cartilage Autograft Implantation System (CAIS) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight...
This study aims to compare longitudinally the effect of adalimumab plus methotrexate (MTX) versus MTX monotherapy on cartilage GAG content, reflected by Delayed Gadolinium-enhanced magneti...
The purpose of this randomized clinical trial was to examine the efficacy of a splinting (fabricated versus off-the-shelf splint)and exercise (nerve and tendon gliding versus no exercise) ...
This study is intended to determine whether the optimal treatment of acute Achilles tendon ruptures is surgical repair or functional bracing. Our hypotheses are surgical repair will: 1) R...
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
Surgical procedure by which a tendon is incised at its insertion and placed at an anatomical site distant from the original insertion. The tendon remains attached at the point of origin and takes over the function of a muscle inactivated by trauma or disease.
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...