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Carnitine Supplementation Modulates High Dietary Copper-Induced Oxidative Toxicity and Reduced Performance in Laying Hens.

Summary of "Carnitine Supplementation Modulates High Dietary Copper-Induced Oxidative Toxicity and Reduced Performance in Laying Hens."

This experiment was conducted to evaluate the effects of
L:
-carnitine on performance, egg quality and certain biochemical parameters in laying hens fed a diet containing high levels of copper proteinate. Forty-eight 42-week-old laying hens were divided into four groups with four replicates. The laying hens were fed with a basal diet (control) or the basal diet supplemented with either 400 mg carnitine (Car)/kg diet, 800 mg copper proteinate (CuP)/kg diet or 400 mg carnitine + 800 mg copper (Car+CuP)/kg diet, for 6 weeks. Supplemental CuP decreased feed consumption (p < 0.01), feed efficiency and egg production (p < 0.001), as compared to control. The combination of Car and CuP increased (p < 0.001) egg production and feed efficiency as compared to CuP. The activities of alanine aminotransferase (p < 0.05) and alkaline phosphatase (p < 0.01) were increased, while lactate dehydrogenase activity was decreased (p < 0.001) by supplemental CuP and Car+CuP. Supplemental CuP caused an increase in plasma malondialdehyde (p < 0.01) and nitric oxide levels (p < 0.05). In the Car+CuP group, this increase was observed to have been reduced significantly (p < 0.05). Furthermore, Car+CuP increased (p < 0.05) glucose level. These results indicate that the carnitine and copper combination may prevent the possible adverse effects of high dietary copper on performance and lipid peroxidation in hens.

Affiliation

Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, University of Erciyes, Kocasinan, 38090, Kayseri, Turkey.

Journal Details

This article was published in the following journal.

Name: Biological trace element research
ISSN: 1559-0720
Pages:

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