Diagnosis of fetal urinary tract malformations: prenatal management and postnatal outcome.

13:22 EST 27th November 2014 | BioPortfolio

Summary of "Diagnosis of fetal urinary tract malformations: prenatal management and postnatal outcome."


OBJECTIVE:
To evaluate prenatal management and to define the criteria of gravity for accurate assessment of the renal and overall prognosis of fetuses presenting malformations of the urinary tract.
METHODS:
We carried out a retrospective study of 127 cases of urinary tract malformation. We carried out descriptive statistical and univariate analyses as a function of severity criteria and the outcome of pregnancy.
RESULTS:
One-third of fetuses presented associated extrarenal malformations and 10% of the karyotypes were abnormal. There were more abortions in case of decrease in amniotic fluid volume (p < 0.001), extent of renal damage (p < 0.05), presence of associated extrarenal malformations (p < 0.05), early diagnosis of the malformation (p < 0.001) and presence of chromosomal syndrome (p = 0.01). In our study, there was an excellent correlation between prenatal data and pathological findings for the fetus following abortions for medical reasons or obtained during the surveillance of live-born children. Fetal biochemistry made very little contribution.
CONCLUSION:
In cases of urinary tract malformation, this work confirms the need for regular and frequent ultrasound scans, checking for the echographic factors indicative of gravity and for adapted karyotyping. It also demonstrates that pluridisciplinary management is necessary for the prenatal evaluation of renal and overall fetal prognosis. Copyright © 2011 John Wiley & Sons, Ltd.

Affiliation

Service de Médecine de l'enfant et de l'adolescent, CHU Rennes et Université Rennes 1, Rennes, France. amelie.ryckewaert@chu-rennes.fr.

Journal Details

This article was published in the following journal.

Name: Prenatal diagnosis
ISSN: 1097-0223
Pages:

Links

PubMed Articles [18715 Associated PubMed Articles listed on BioPortfolio]

Does prenatal diagnosis modify neonatal management and early outcome of children with esophageal atresia?

Our study aimed at (1) evaluating neonatal management and outcome of neonates with either a prenatal or a postnatal diagnosis of EA (2) analyzing the impact of prenatal diagnosis on outcome based on t...

Advances in evaluating the fetal skeleton.

In this review, we discuss aspects of the prenatal diagnosis of fetal skeletal malformations, concentrating on the advantages offered by different imaging techniques and the approaches that are of val...

Diagnosis and Management of Urinary Tract Infections in the Outpatient Setting: A Review.

Urinary tract infection is among the most common reasons for an outpatient visit and antibiotic use in adult populations. The increasing prevalence of antibacterial resistance among community uropatho...

Fetal cardiac disease and fetal lung volume: an in utero MRI investigation.

Magnetic resonance imaging (MRI) is a powerful, noninvasive tool to study fetal lung volumes after 18 weeks of gestation in vivo. In neonates with congenital heart disease (CHD), proper lung functio...

Manufacturing Models of Fetal Malformations Built From 3-Dimensional Ultrasound, Magnetic Resonance Imaging, and Computed Tomography Scan Data.

Technological innovations accompanying advances in medicine have given rise to the possibility of obtaining better-defined fetal images that assist in medical diagnosis and contribute toward genetic c...

Clinical Trials [3472 Associated Clinical Trials listed on BioPortfolio]

Development of an Optimal Approach to Return of Results for Families Undergoing Next-generation Sequencing for Prenatal Diagnosis

To gain knowledge about how patients undergoing prenatal diagnosis for a fetal abnormality understand and react to Whole Genome Sequencing (WGS) testing, so that the investigators can deve...

Comparison of Abnormal Cortical Development in Brain Malformations on Postmortem Imaging With Autopsy

Examination of the fetal brain at autopsy is technically challenging because of marked fragility of the brain tissue. Studies have found postmortem fetal MR to be particularly useful in ex...

Safety and Efficacy of Canephron® N in the Management of Uncomplicated Urinary Tract Infections (uUTI)

The objective of the study is to assess safety and impact of a non-antibiotic therapy approach with Canephron® N in the management strategy of uncomplicated lower urinary tract infections...

Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure

The purpose of this study is to determine if choline bitartrate can be administered daily to children with prenatal alcohol exposure, ages 2.5 to 5, as a potential treatment for brain deve...

Fetal Anatomy by Three-Dimensional Ultrasound

A major goal of perinatal care is to accurately diagnose fetal anomalies prior to birth. This capability allows clinicians to make prudent decisions regarding antepartum care, delivery sit...

Medical and Biotech [MESH] Definitions

A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.

A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.

Prenatal interventions to correct fetal anomalies or treat FETAL DISEASES in utero. Fetal therapies include several major areas, such as open surgery; FETOSCOPY; pharmacological therapy; INTRAUTERINE TRANSFUSION; STEM CELL TRANSPLANTATION; and GENE THERAPY.

Properties, functions, and processes of the URINARY TRACT as a whole or of any of its parts.

Functions and activities of the URINARY TRACT as a whole or of any of its parts.

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Urology
Latest News Clinical Trials Research Drugs Reports Corporate
Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Follow and track Urology News on BioPortfolio: Uro...

Top five promising drugs Phase I (November 2013)
Latest News Clinical Trials Research Drugs Reports Corporate
THE FIVE MOST PROMISING DRUGS ENTERING PHASE I TRIALS Drug Disease Company ARC-520 Hepatitis B virus infection Arrowhead Research GR-MD-02 Non-alcoholic steatohepatitis ...

Obstetrics and gynaecology
Latest News Clinical Trials Research Drugs Reports Corporate
Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultants are generalists but the specialty offers a wide range of sub-specialties, which include materno-fetal...

Advertisement