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Diagnosis of fetal urinary tract malformations: prenatal management and postnatal outcome.

06:00 EDT 12th July 2011 | BioPortfolio

Summary of "Diagnosis of fetal urinary tract malformations: prenatal management and postnatal outcome."


OBJECTIVE:
To evaluate prenatal management and to define the criteria of gravity for accurate assessment of the renal and overall prognosis of fetuses presenting malformations of the urinary tract.
METHODS:
We carried out a retrospective study of 127 cases of urinary tract malformation. We carried out descriptive statistical and univariate analyses as a function of severity criteria and the outcome of pregnancy.
RESULTS:
One-third of fetuses presented associated extrarenal malformations and 10% of the karyotypes were abnormal. There were more abortions in case of decrease in amniotic fluid volume (p < 0.001), extent of renal damage (p < 0.05), presence of associated extrarenal malformations (p < 0.05), early diagnosis of the malformation (p < 0.001) and presence of chromosomal syndrome (p = 0.01). In our study, there was an excellent correlation between prenatal data and pathological findings for the fetus following abortions for medical reasons or obtained during the surveillance of live-born children. Fetal biochemistry made very little contribution.
CONCLUSION:
In cases of urinary tract malformation, this work confirms the need for regular and frequent ultrasound scans, checking for the echographic factors indicative of gravity and for adapted karyotyping. It also demonstrates that pluridisciplinary management is necessary for the prenatal evaluation of renal and overall fetal prognosis. Copyright © 2011 John Wiley & Sons, Ltd.

Affiliation

Service de Médecine de l'enfant et de l'adolescent, CHU Rennes et Université Rennes 1, Rennes, France. amelie.ryckewaert@chu-rennes.fr.

Journal Details

This article was published in the following journal.

Name: Prenatal diagnosis
ISSN: 1097-0223
Pages:

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Medical and Biotech [MESH] Definitions

A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.

A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.

Prenatal interventions to correct fetal anomalies or treat FETAL DISEASES in utero. Fetal therapies include several major areas, such as open surgery; FETOSCOPY; pharmacological therapy; INTRAUTERINE TRANSFUSION; STEM CELL TRANSPLANTATION; and GENE THERAPY.

Properties, functions, and processes of the URINARY TRACT as a whole or of any of its parts.

Functions and activities of the URINARY TRACT as a whole or of any of its parts.

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