Once daily controlled release matrix tablet of Prochlorperazine maleate: Influence of Ethocel(?) and/or Methocel(?) on in vitro drug release and bioavailability.
Summary of "Once daily controlled release matrix tablet of Prochlorperazine maleate: Influence of Ethocel(?) and/or Methocel(?) on in vitro drug release and bioavailability."
Context: Controlled release (CR) matrix tablet of Prochlorperazine maleate was developed to improve its patient compliance. Methods: Tablet formulations F1, F2 and F3 based on different concentrations of Methocel(?) K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of Methocel(?) K100 LV-CR Premium and Ethocel(?) Standard 7FP Premium, were compressed by flow-bound dry granulation-slugging method. The prepared powder mixtures, granules and tablets were evaluated for their physicochemical performance. Bioequivalence study of the optimized test tablet versus reference-conventional Stemitil(?) tablet was conducted on rabbits, using HPLC-UV system at ?(max) 254?nm. Results: The test tablet, containing 28% Methocel(?) and 58% Ethocel(?) (F6) exhibited desired zero order kinetics for 24?h and was found stable at accelerated storage conditions for 6 months. In vitro drug release rate decreased as the Ethocel(?) content in the blend was increased, perhaps due to slower penetrability of water. Hydrodynamic conditions and hardness of tablets could not affect drug release kinetics. The tablet displayed significantly (p?
Affiliation
Pharmacy, Univeristy of Peshawar , Peshawar 25120 Pakistan.
Journal Details
This article was published in the following journal.
Name: Drug development and industrial pharmacy
ISSN: 1520-5762
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21749268
- DOI: http://dx.doi.org/10.3109/03639045.2011.595416
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