Acute pandysautonomia - restitutio ad integrum by high prednisolone therapy.
Summary of "Acute pandysautonomia - restitutio ad integrum by high prednisolone therapy."
Acute pandysautonomia is a rare disease defined as acute widespread and severe sympathetic and parasympathetic failure and sparing of somatic nerve fibers. The causes of this syndrome are often an autoimmune disease leading to autonomic ganglionopathy. The majority of cases have a poor prognosis with a chronic debilitating course. We present a previously healthy 24-year-old female patient, who developed a loss of accommodation, pupillotonia, lacrimation, swallowing disturbances, gastrointestinal symptoms and an atonic bladder with 750 ml residual volume. The Ewing battery showed signs of parasympathetic and sympathetic dysfunction leading to the diagnosis of acute pandysautonomia. Further tests failed to find a cause of acute neuropathy especially where there was no evidence for paraneoplastic or infectious etiology. The patient was treated with high dose intravenous prednisolone and completely recovered.
Department for Neurology and Psychiatry, Autonomic Unit, AKH, Linz, Austria, firstname.lastname@example.org.
This article was published in the following journal.
Name: Wiener klinische Wochenschrift
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21766230
- DOI: http://dx.doi.org/10.1007/s00508-011-0030-z
Medical and Biotech [MESH] Definitions
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