Naphthylthiourea-modified permethylcyclodextrin as a highly sensitive and selective "turn-on" fluorescent chemosensor for Hg(2+) in water and living cells.
Summary of "Naphthylthiourea-modified permethylcyclodextrin as a highly sensitive and selective "turn-on" fluorescent chemosensor for Hg(2+) in water and living cells."
A naphthylthiourea-modified cyclodextrin (1) and its urea derivative (2) were synthesized, and their fluorescence behaviors in the presence of various metal ions were investigated. Significantly, 1 showed a highly sensitive and selective fluorescence sensing ability for Hg(2+) over other metal ions in both water and living cells. That is, the addition of Hg(2+) to an aqueous solution of 1 gave a significantly enhanced fluorescence at ∼380 nm. In contrast, the addition of other metal ions induced negligible fluorescence changes. The possible mechanism may be due to the transformation of thiourea to urea by Hg(2+)-induced desulfurization in water.
Affiliation
Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China. yuliu@nankai.edu.cn.
Journal Details
This article was published in the following journal.
Name: Organic & biomolecular chemistry
ISSN: 1477-0539
Pages: 5530-4
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21695320
- DOI: http://dx.doi.org/10.1039/c1ob05221g
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