Metformin abolishes increased tumor ( 18) F-2-Fluoro-2-Deoxy-D-Glucose uptake associated with a high-energy diet.

17:57 EDT 23rd October 2014 | BioPortfolio

Summary of "Metformin abolishes increased tumor ( 18) F-2-Fluoro-2-Deoxy-D-Glucose uptake associated with a high-energy diet."

Insulin regulates glucose uptake by normal tissues. Although there is evidence that certain cancers are growth-stimulated by insulin, the possibility that insulin influences tumor glucose uptake as assessed by ( 18) F-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography (FDG-PET) has not been studied in detail. We present a model of diet-induced hyperinsulinemia associated with increased insulin receptor activation in neoplastic tissue, and with increased tumor FDG-PET image intensity. Metformin abolished the diet-induced increases in serum insulin level, tumor insulin receptor activation, and tumor FDG uptake associated with the high-energy diet, but had no effect on these measurements in mice on a control diet. These findings provide the first functional imaging correlate of the well-known adverse effect of caloric excess on cancer outcome. They demonstrate that for a subset of neoplasms, diet and insulin are variables that affect tumor FDG uptake, and have implications for design of clinical trials of metformin as an anti-neoplastic agent.

Affiliation

Department of Experimental Medicine; McGill University and Cancer Prevention Center; SMBD-Jewish General Hospital; McGill University; Montreal, QC, Canada.

Journal Details

This article was published in the following journal.

Name: Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Pages:

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