Advertisement

Topics

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

06:00 EDT 16th August 2011 | BioPortfolio

Summary of "Pericytes: developmental, physiological, and pathological perspectives, problems, and promises."

Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology.

Affiliation

Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77 Stockholm, Sweden; Institute of Neuropathology, University Hospital Zürich, CH-8091 Zürich, Switzerland.

Journal Details

This article was published in the following journal.

Name: Developmental cell
ISSN: 1878-1551
Pages: 193-215

Links

DeepDyve research library

PubMed Articles [12104 Associated PubMed Articles listed on BioPortfolio]

Validation of a culturally adapted developmental screening tool for Australian Aboriginal children: Early findings and next steps.

Early detection of developmental problems is important for facilitating access to targeted intervention and maximising its positive effects. The later problems are identified, the more likely that the...

Developmental and physical-fitness associations with gross motor coordination problems in Peruvian children.

The aims of this cross-sectional study were to examine the developmental characteristics (biological maturation and body size) associated with gross motor coordination problems in 5193 Peruvian childr...

Early detection of parenting and developmental problems in young children: Non-randomized comparison of visits to the well-baby clinic with or without a validated interview.

Determine whether the early detection of parenting problems and developmental problems in young children improves with the help of a validated structured interview.

Using Parent Evaluation of Developmental Status (PEDS) for Screening: the Thai Experience.

Parent Evaluation of Developmental Status (PEDS) is feasible developmental screening tools; however, it is not commonly used in Thailand. To examine the potential of PEDS as a screening mechanism, PED...

Physiological and pathological cardiac hypertrophy.

The heart must continuously pump blood to supply the body with oxygen and nutrients. To maintain the high energy consumption required by this role, the heart is equipped with multiple complex biologic...

Clinical Trials [2174 Associated Clinical Trials listed on BioPortfolio]

Translating Evidence Based Developmental Screening Into Pediatric Primary Care

The purpose of this study is to examine the feasibility, acceptability and effectiveness of implementing the AAP's recommendation that clinicians provide developmental surveillance at all ...

Poker, Skills and Associated Problems

The PERHAPS project aims to fill two gaps in the scientific literature: on the one hand, studying the clinical and cognitive particularities of poker-related problems, and on the other han...

Ecological Momentary Assessment of Eating Behavior in Overweight Youth

The current study seeks to elucidate the context of pathological and non-pathological eating behavior in a heterogeneous sample of overweight and obese children, aged 8-14 years. Children ...

Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes

By testing physiological responses to anxiety in people with nervous system developmental disorders, this study will identify specific physiological characteristics associated with respons...

Developmental Dyslexia and Functional Maturation of Auditory Cortex

Developmental dyslexia is a frequent learning disability. The aim of this study is to compare auditory evoked cortical responses to syllables and tones in developmental dyslexia and contro...

Medical and Biotech [MESH] Definitions

The branch of medicine concerned with the physiological and pathological aspects of the aged, including the clinical problems of senescence and senility.

Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.

The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.

Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.

A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Diabetes
Diabetes is a lifelong condition that causes a person's blood sugar level to become too high. The two main types of diabetes are: type 1 diabetes type 2 diabetes In the UK, diabetes affects approximately 2.9 million people. There are a...


Searches Linking to this Article