Vasomotor symptoms and cardiovascular disease risk.
Summary of "Vasomotor symptoms and cardiovascular disease risk."
ABSTRACT Although the exact etiology of hot flushes and night sweats has not been fully clarified, the intriguing question whether vasomotor symptoms (VMS) are markers of coronary artery disease risk has been evaluated in several studies. Surrogate metabolic and hemodynamic parameters point at adverse alterations in flushers, but the results related to clinical endpoints are not unidirectional. Recent relevant data come from the Women's Health Initiative (WHI) observational study (60 000 women, mean age 63 years, mean follow-up period 10 years). Women with VMS only at onset of menopause but not at enrollment to the WHI study had a modest, yet significant decreased risk of stroke, total cardiovascular disease events, and all-cause mortality, compared with women having no VMS. Contrarily, women with late VMS (reported at enrollment to the study but not at onset of menopause) had an increased risk in the above-mentioned parameters. There was no interaction between hormone use and VMS in this respect. This mini-review, which summarizes the relevant data, shows that hot flushes seem to be a marker for physiological alterations that could be associated with cardiovascular disease.
Department of Medicine 'T', Ichilov Hospital , Tel-Aviv , Israel.
This article was published in the following journal.
Name: Climacteric : the journal of the International Menopause Society
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21848496
- DOI: http://dx.doi.org/10.3109/13697137.2011.599058
An association between erectile dysfunction and cardiovascular disease has long been recognized, and studies suggest that erectile dysfunction is an independent marker of cardiovascular disease risk....
Depressive symptoms are an independent risk factor of cardiovascular disease (CVD). More than 15% of persons with CVD have depressive symptoms, which are twice as likely to occur in women. Depressive...
Menopausal hormone therapy (HT) continues to have a clinical role in symptom management, but identifying women for whom benefits will outweigh the risks remains a challenge. Although hormone therapy (...
Cardiovascular disease is the leading cause of death in the United States. Testosterone is the principal male sex hormone and plays an important role in men's health and well-being. Historically, test...
The purpose of this study was to investigate associations between profiles of vasomotor menopausal symptoms (VMS) during the menopausal transition with the prevalence of diabetes.
Chronic rhinitis without an allergic or infectious aetiology (vasomotor rhinitis) is a common disease for which there are only poor therapeutic treatment options. The current placebo contr...
The purpose of this study is to assess the efficacy and safety of 4 doses of desvenlafaxine-233 sustained release (DVS-233 SR) as compared to placebo for the treatment of moderate to sever...
The primary purpose of this study is to determine the effects of a full dose (300 mg at hs) of oral micronized progesterone (OMP) on vasomotor symptoms [VMS] (hot flushes/night sweats), on...
The study evaluates in Chinese post-menopausal women the combination of drospirenone 2 mg and estradiol 1 mg for the treatment of climacteric symptoms, such as hot flushes (vasomotor sympt...
To determine whether the presence of endothelial dysfunction is an independent risk factor for cardiovascular disease events.
Medical and Biotech [MESH] Definitions
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.