Photo-oxidation of proteins.

19:51 EDT 31st March 2015 | BioPortfolio

Summary of "Photo-oxidation of proteins."

Photo-induced damage to proteins occurs via multiple pathways. Direct damage induced by UVB (λ 280-320 nm) and UVA radiation (λ 320-400 nm) is limited to a small number of amino acid residues, principally tryptophan (Trp), tyrosine (Tyr), histidine (His) and disulfide (cystine) residues, with this occurring via both excited state species and radicals. Indirect protein damage can occur via singlet oxygen ((1)O(2)(1)Δ(g)), with this resulting in damage to Trp, Tyr, His, cystine, cysteine (Cys) and methionine (Met) residues. Although initial damage is limited to these residues multiple secondary processes, that occur both during and after radiation exposure, can result in damage to other intra- and inter-molecular sites. Secondary damage can arise via radicals (e.g. Trp, Tyr and Cys radicals), from reactive intermediates generated by (1)O(2) (e.g. Trp, Tyr and His peroxides) and via molecular reactions of photo-products (e.g. reactive carbonyls). These processes can result in protein fragmentation, aggregation, altered physical and chemical properties (e.g. hydrophobicity and charge) and modulated biological turnover. Accumulating evidence implicates these events in cellular and tissue dysfunction (e.g. apoptosis, necrosis and altered cell signaling), and multiple human pathologies.


The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia.

Journal Details

This article was published in the following journal.

Name: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society
ISSN: 1474-9092


PubMed Articles [8601 Associated PubMed Articles listed on BioPortfolio]

Photo-Fenton-like treatment of K-acid: assessment of treatability, toxicity and oxidation products.

Photo-Fenton-like treatment of the commercially important naphthalene sulphonate K-acid (2-naphthylamine-3,6,8-trisulphonic acid) was investigated using UV-C, UV-A and visible light irradiation. Chang...

Kinetics and mechanism of photo-promoted oxidative dissolution of antimony trioxide.

Light (sunlight, ultraviolet, simulated sunlight) irradiation was used to initiate the dissolution of antimony trioxide (Sb2O3). Dissolution rate of Sb2O3 was accelerated and dissolved trivalent antim...

Mature landfill leachate treatment by coagulation/flocculation combined with Fenton and solar photo-Fenton processes.

This work reports the treatment of a mature landfill leachate through the application of chemical-based treatment processes in order to achieve the discharge legal limits into natural water courses. F...

The kinetics and mechanism of photo-assisted Ag(i)-catalysed water oxidation with S2O8(2-)

The kinetics of photo-assisted Ag(i)-catalysed water oxidation into O2 with S2O8(2-) has been investigated. When the concentration of Ag(+) is less than 7.06 × 10(-3) mol L(-1), O2-evolution under vi...

Atmospheric Gas Phase Chemistry of CH2=NH and HNC. A First Principles Approach.

ABSTRACT Quantum chemical methods were used to investigate the OH initiated atmospheric degradation of methanimine, CH2=NH - the major primary product in the atmospheric photo-oxidation of methylamine...

Clinical Trials [608 Associated Clinical Trials listed on BioPortfolio]

Medium-Dose UVA1 Versus Narrow-Band UVB in Atopic Dermatitis

Atopic dermatitis (AD) is a very common disorder that is characterized by pruritic inflammatory skin lesions, with patients usually having an individual or family history of atopic disease...

Study of Protein Translocation in Patients With Beta-Oxidation Disorders

OBJECTIVES: I. Characterize inheritance patterns of mutations in patients with beta-oxidation disorders.

Dermacyd Delicata Pocket BR - Photo Evaluation

The purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product Dermacyd Delicata Pocket BR.

Study of LED Phototherapy for Musculoligamentous Lesions

The purpose of this study is to determine whether LED phototherapy using combined red and near infrared light (approved: Ministry of Health of Russian Federation No. 29/06070997/1080-00, E...

Dermacyd Tina Gel Sweet Flower - Photo Evaluation

The purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product Dermacyd Tina Gel Sweet Flower.

Medical and Biotech [MESH] Definitions

Proteins, usually acting in oxidation-reduction reactions, containing iron but no porphyrin groups. (Lehninger, Principles of Biochemistry, 1993, pG-10)

An enzyme that catalyzes the reactivation by light of UV-irradiated DNA. It breaks two carbon-carbon bonds in PYRIMIDINE DIMERS in DNA.

A photo-active pigment localized in prolamellar bodies occurring within the proplastids of dark-grown bean leaves. In the process of photoconversion, the highly fluorescent protochlorophyllide is converted to chlorophyll.

Compounds used extensively as acetylation, oxidation and dehydrating agents and in the modification of proteins and enzymes.

Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

Search BioPortfolio: