Herpes Simplex Virus Genital Infections: Current Concepts.
Summary of "Herpes Simplex Virus Genital Infections: Current Concepts."
Genital herpes is a common sexually transmitted disease that is frequently undiagnosed. Viral shedding occurs frequently and often without symptoms facilitating transmission to sex partners. Genital herpes may impact HIV transmission, and may be transmitted to neonates at the time of birth. Primary prevention of genital herpes is needed to lower the burden of disease.
Affiliation
Departments of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA, 98195-6460, USA, cgardel@u.washington.edu.
Journal Details
This article was published in the following journal.
Name: Current infectious disease reports
ISSN: 1534-3146
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21861067
- DOI: http://dx.doi.org/10.1007/s11908-011-0209-5
Medical and Biotech [MESH] Definitions
Herpes Simplex Virus Protein Vmw65
Trans-acting protein that combines with host factors to induce immediate early gene transcription in herpes simplex virus.
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
Host Cell Factor C1
A cellular transcriptional coactivator that was originally identified by its requirement for the stable assembly IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. It is a nuclear protein that is a transcriptional coactivator for a number of transcription factors including VP16 PROTEIN; GA-BINDING PROTEIN; EARLY GROWTH RESPONSE PROTEIN 2; and E2F4 TRANSCRIPTION FACTOR. It also interacts with and stabilizes HERPES SIMPLEX VIRUS PROTEIN VMW65 and helps regulate GENETIC TRANSCRIPTION of IMMEDIATE-EARLY GENES in HERPES SIMPLEX VIRUS.
Herpes Genitalis
Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.
Aids-related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
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